Autologous Bone Marrow Mononuclear Cells (BMMC)-Associated Anti-Inflammatory Nanoparticles for Cardiac Repair after Myocardial Infarction

To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic MI. Chronic myocardial infarction (MI) was induced by the ligation of the left anterior descending artery in 40 male Wistar...

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Published inJournal of functional biomaterials Vol. 13; no. 2; p. 59
Main Authors Uemura, Laercio, Baggio Simeoni, Rossana, Bispo Machado Júnior, Paulo André, Gavazzoni Blume, Gustavo, Kremer Gamba, Luize, Sgarbossa Tonial, Murilo, Baggio Simeoni, Paulo Ricardo, Stadler Tasca Ribeiro, Victoria, Silvestre, Rodrigo, de Carvalho, Katherine Athayde Teixeira, Napimoga, Marcelo Henrique, Cesar Francisco, Júlio, Guarita-Souza, Luiz Cesar
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.05.2022
MDPI
Subjects
15d-PGJ2
Angiogenesis
Animal models
anti-inflammatory
Antibodies
Autografts
Bone marrow
bone marrow mononuclear cells
Bone marrow transplantation
Bone surgery
Connexin 43
Coronary vessels
Echocardiography
Electrical junctions
Flow cytometry
Gap junctions
Heart attacks
Inflammation
Injection
Laboratory animals
Leukocytes (mononuclear)
Myocardial Infarction
Myocardium
Nanoparticles
Ostomy
rats
Statistical analysis
Stem cell transplantation
Stem cells
Surgery
Transplantation
United States > US
Germany
anti-inflammatory
bone marrow mononuclear cells
Myocardial Infarction
rats
15d-PGJ2
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Abstract To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic MI. Chronic myocardial infarction (MI) was induced by the ligation of the left anterior descending artery in 40 male Wistar rats. After surgery, we transplanted bone marrow associated with 15d-PGJ2-loaded nanoparticle by intramyocardial injection (10 cells/per injection) seven days post-MI. Myocardial infarction was confirmed by echocardiography, and histological analyses of infarct morphology, gap junctions, and angiogenesis were obtained. Our results from immunohistochemical analyses demonstrated the presence of angiogenesis identified in the transplanted region and that there was significant expression of connexin-43 gap junctions, showing a more effective electrical and mechanical integration of the host myocardium. This study suggests that the application of nanoparticle technology in the prevention and treatment of MI is an emerging field and can be a strategy for cardiac repair.
AbstractList To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic MI. Chronic myocardial infarction (MI) was induced by the ligation of the left anterior descending artery in 40 male Wistar rats. After surgery, we transplanted bone marrow associated with 15d-PGJ2-loaded nanoparticle by intramyocardial injection (106 cells/per injection) seven days post-MI. Myocardial infarction was confirmed by echocardiography, and histological analyses of infarct morphology, gap junctions, and angiogenesis were obtained. Our results from immunohistochemical analyses demonstrated the presence of angiogenesis identified in the transplanted region and that there was significant expression of connexin-43 gap junctions, showing a more effective electrical and mechanical integration of the host myocardium. This study suggests that the application of nanoparticle technology in the prevention and treatment of MI is an emerging field and can be a strategy for cardiac repair.
To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic MI. Chronic myocardial infarction (MI) was induced by the ligation of the left anterior descending artery in 40 male Wistar rats. After surgery, we transplanted bone marrow associated with 15d-PGJ2-loaded nanoparticle by intramyocardial injection (10 cells/per injection) seven days post-MI. Myocardial infarction was confirmed by echocardiography, and histological analyses of infarct morphology, gap junctions, and angiogenesis were obtained. Our results from immunohistochemical analyses demonstrated the presence of angiogenesis identified in the transplanted region and that there was significant expression of connexin-43 gap junctions, showing a more effective electrical and mechanical integration of the host myocardium. This study suggests that the application of nanoparticle technology in the prevention and treatment of MI is an emerging field and can be a strategy for cardiac repair.
To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat model of chronic MI. Chronic myocardial infarction (MI) was induced by the ligation of the left anterior descending artery in 40 male Wistar rats. After surgery, we transplanted bone marrow associated with 15d-PGJ2-loaded nanoparticle by intramyocardial injection (10 6 cells/per injection) seven days post-MI. Myocardial infarction was confirmed by echocardiography, and histological analyses of infarct morphology, gap junctions, and angiogenesis were obtained. Our results from immunohistochemical analyses demonstrated the presence of angiogenesis identified in the transplanted region and that there was significant expression of connexin-43 gap junctions, showing a more effective electrical and mechanical integration of the host myocardium. This study suggests that the application of nanoparticle technology in the prevention and treatment of MI is an emerging field and can be a strategy for cardiac repair.
Author Stadler Tasca Ribeiro, Victoria
Silvestre, Rodrigo
Uemura, Laercio
Sgarbossa Tonial, Murilo
Kremer Gamba, Luize
Bispo Machado Júnior, Paulo André
Cesar Francisco, Júlio
Baggio Simeoni, Rossana
Gavazzoni Blume, Gustavo
Guarita-Souza, Luiz Cesar
de Carvalho, Katherine Athayde Teixeira
Napimoga, Marcelo Henrique
Baggio Simeoni, Paulo Ricardo
AuthorAffiliation 2 Instituto de Radiologia (InRad), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-070, Brazil; rodrigogms@usp.br
4 Institute and Research Center São Leopoldo Mandic, São Leopoldo Mandic, Faculty–SLMANDIC, Campinas, São Paulo 13045-775, Brazil; marcelo.napimga@gmail.com
3 Cell Therapy and Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, 1632 Silva Jardim Avenue, Curitiba 80240-020, Brazil; katherinecav@gmail.com
1 Experimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), 1555 Imaculada Conceição Street, Curitiba 80215-901, Brazil; l.uemura@hotmail.com (L.U.); paulo_vicmar@hotmail.com (P.A.B.M.J.); gustavoblume@gmail.com (G.G.B.); luizekremer@hotmail.com (L.K.G.); murilotonial@gmail.com (M.S.T.); prbaggiosimeoni@hotmail.com (P.R.B.S.); vicstadler@gmail.com (V.S.T.R.); juli
AuthorAffiliation_xml – name: 2 Instituto de Radiologia (InRad), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05508-070, Brazil; rodrigogms@usp.br
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– name: 3 Cell Therapy and Biotechnology in Regenerative Medicine Department, The Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research & Pequeno Príncipe Faculties, 1632 Silva Jardim Avenue, Curitiba 80240-020, Brazil; katherinecav@gmail.com
– name: 1 Experimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), 1555 Imaculada Conceição Street, Curitiba 80215-901, Brazil; l.uemura@hotmail.com (L.U.); paulo_vicmar@hotmail.com (P.A.B.M.J.); gustavoblume@gmail.com (G.G.B.); luizekremer@hotmail.com (L.K.G.); murilotonial@gmail.com (M.S.T.); prbaggiosimeoni@hotmail.com (P.R.B.S.); vicstadler@gmail.com (V.S.T.R.); julio.apfr@gmail.com (J.C.F.); guaritasouzalc@hotmail.com (L.C.G.-S.)
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Issue 2
Keywords anti-inflammatory
bone marrow mononuclear cells
Myocardial Infarction
rats
15d-PGJ2
Language English
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Snippet To investigate the effect of transplantation of stem cells from the bone marrow mononuclear cells (BMMC) associated with 15d-PGJ2-loaded nanoparticles in a rat...
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StartPage 59
SubjectTerms 15d-PGJ2
Angiogenesis
Animal models
anti-inflammatory
Antibodies
Autografts
Bone marrow
bone marrow mononuclear cells
Bone marrow transplantation
Bone surgery
Connexin 43
Coronary vessels
Echocardiography
Electrical junctions
Flow cytometry
Gap junctions
Heart attacks
Inflammation
Injection
Laboratory animals
Leukocytes (mononuclear)
Myocardial Infarction
Myocardium
Nanoparticles
Ostomy
rats
Statistical analysis
Stem cell transplantation
Stem cells
Surgery
Transplantation
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Title Autologous Bone Marrow Mononuclear Cells (BMMC)-Associated Anti-Inflammatory Nanoparticles for Cardiac Repair after Myocardial Infarction
URI https://www.ncbi.nlm.nih.gov/pubmed/35645267
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