A case of cardiac dysfunction associated with monoclonal gammopathy of undetermined significance

The monoclonal gammopathies (MG) are monoclonal neoplasms related to each other by virtue of their development from common progenitors in the B lymphocyte lineage. Cardiac dysfunction in patients with MG is not well established. We experienced a case of cardiac dysfunction associated with MG identif...

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Published inJournal of Korean medical science Vol. 24; no. 2; pp. 354 - 356
Main Authors Jang, Suk-Tae, Sohn, Il-Suk, Jin, Eun-Sun, Cho, Jin-Man, Kim, Chong-Jin, Lim, Sung-Jig
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Academy of Medical Sciences 01.04.2009
대한의학회
Subjects
Bone Marrow - pathology
Cardiomyopathies - diagnosis
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - etiology
Case Report
Humans
Immunoglobulin kappa-Chains - analysis
Male
Middle Aged
Paraproteinemias - complications
Paraproteinemias - pathology
Ultrasonography
의학일반
Paraproteinemias
Echocardiography
Ventricular Dysfunction
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Summary:The monoclonal gammopathies (MG) are monoclonal neoplasms related to each other by virtue of their development from common progenitors in the B lymphocyte lineage. Cardiac dysfunction in patients with MG is not well established. We experienced a case of cardiac dysfunction associated with MG identified by echocardiography and biopsy. Fifty nine year-old man was admitted because of dyspnea for several months. Echocardiography revealed diastolic dysfunction showing restrictive physiology with elevated left ventricular filling pressure. Bone marrow (BM) studies and immunoelectrophoresis were compatible with monoclonal gammopathy of undetermined significance. Endomyocardial, BM, and enteral biopsies for ruling out for amyloidosis (Congo-red stain) were negative. This is the case of non-amyloidotic light chain deposition cardiomyopathy.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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G704-000345.2009.24.2.019
ISSN:1011-8934
1598-6357
DOI:10.3346/jkms.2009.24.2.354