Tumour DNA ploidy as an independent prognostic factor in breast cancer

We determined nuclear DNA content from 308 archival paraffin-embedded malignant breast tumours and evaluated the survival of the patients by univariate and multivariate statistical analyses. The overall 8-year survival rate of stage I-III breast cancer patients was 74.3% in DNA-diploid and 51.2% in...

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Bibliographic Details
Published inBritish journal of cancer Vol. 56; no. 5; pp. 637 - 642
Main Authors KALLIONIEMI, O.-P, BLANCO, G, ALAVAIKKO, M, HIETANEN, T, MATTILA, J, LAUSLAHTI, K, KOIVULA, T
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.11.1987
Subjects
Aged
Biological and medical sciences
Breast Neoplasms - analysis
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Diploidy
DNA, Neoplasm - analysis
Female
Flow Cytometry
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Lymph Nodes - pathology
Mammary gland diseases
Medical sciences
Middle Aged
Neoplasm Staging
Ploidies
Prognosis
Receptors, Progesterone - analysis
Time Factors
Tumors
Human
Ploidy
Prognosis
DNA
Tumor
Mammary gland
Woman
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Summary:We determined nuclear DNA content from 308 archival paraffin-embedded malignant breast tumours and evaluated the survival of the patients by univariate and multivariate statistical analyses. The overall 8-year survival rate of stage I-III breast cancer patients was 74.3% in DNA-diploid and 51.2% in DNA-aneuploid tumours (P less than 0.0001). DNA ploidy had prognostic significance in both node-negative and node-positive breast cancer, primarily in cases with steroid receptor-positive tumours. In a Cox multivariate analysis DNA ploidy (P = 0.001), primary tumour size (P = 0.0007), nodal status (P = 0.04) and the content of progesterone receptors (P = 0.0008) emerged as significant independent prognostic factors, whereas oestrogen receptor status, age and menopausal status of the patients had no significant independent prognostic value. If the histological grade of ductal carcinomas was also included in the Cox model, both grade and DNA ploidy had independent prognostic effect. In conclusion, our results indicate that the analysis of DNA ploidy is a useful adjunct in the assessment of prognosis for breast cancer patients.
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ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1987.258