Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis

The genome sequence of Bacillus subtilis was published in 1997 and since then many other bacterial genomes have been sequenced, among them Bacillus licheniformis in 2004. B. subtilis and B. licheniformis are closely related and feature similar saprophytic lifestyles in the soil. Both species can sec...

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Published inJournal of molecular microbiology and biotechnology Vol. 16; no. 1-2; pp. 53 - 68
Main Authors Voigt, Birgit, Antelmann, Haike, Albrecht, Dirk, Ehrenreich, Armin, Maurer, Karl-Heinz, Evers, Stefan, Gottschalk, Gerhard, van Dijl, Jan Maarten, Schweder, Thomas, Hecker, Michael
Format Journal Article
LanguageEnglish
Published Switzerland S. Karger AG 01.01.2009
Subjects
Bacillus - growth & development
Bacillus - metabolism
Bacillus - physiology
Bacillus subtilis - growth & development
Bacillus subtilis - metabolism
Bacillus subtilis - physiology
Bacterial Proteins - genetics
Bacterial Proteins - secretion
Biological Transport
Cell Physiological Phenomena
Growth conditions
Nutrient availability
Nutrient sources
Protein Sorting Signals
Proteins
Proteome - genetics
Proteome - metabolism
Translocation
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Summary:The genome sequence of Bacillus subtilis was published in 1997 and since then many other bacterial genomes have been sequenced, among them Bacillus licheniformis in 2004. B. subtilis and B. licheniformis are closely related and feature similar saprophytic lifestyles in the soil. Both species can secrete numerous proteins into the surrounding medium enabling them to use high-molecular-weight substances, which are abundant in soils, as nutrient sources. The availability of complete genome sequences allows for the prediction of the proteins containing signals for secretion into the extracellular milieu and also of the proteins which form the secretion machinery needed for protein translocation through the cytoplasmic membrane. To confirm the predicted subcellular localization of proteins, proteomics is the best choice. The extracellular proteomes of B. subtilis and B. licheniformis have been analyzed under different growth conditions allowing comparisons of the extracellular proteomes and conclusions regarding similarities and differences of the protein secretion mechanisms between the two species.
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ISSN:1464-1801
1660-2412
DOI:10.1159/000142894