Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans

• Published in: Journal of applied physiology (1985) Vol. 86; no. 3; pp. 806 - 811
• Main Authors: Kjar, M, Pott, F, Mohr, T, Linkis, P, Tornoe, P, Secher, N. H
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.03.1999; American Physiological Society
• Subjects: Adult; Bicycling; Biological and medical sciences; Blood pressure; Blood Pressure - physiology; Electric Stimulation; Exercise; Exercise - physiology; Female; Fundamental and applied biological sciences. Psychology; Heart; Heart Rate - physiology; Humans; Ischemia - physiopathology; Leg - blood supply; Leg - physiology; Legs; Male; Paraplegia - physiopathology; Quadriplegia - physiopathology; Regional Blood Flow - physiology; Respiratory Mechanics - physiology; Rest - physiology; Spinal cord injuries; Spinal Cord Injuries - physiopathology; Vertebrates: cardiovascular system; Physical exercise; Human; Nervous system diseases; Nervous control; Motor system disorder; Electrical stimulus; Central nervous system; Lower limb; Feedback regulation; Physical handicap; Heart rate; Paraplegia; Blood pressure; Hemodynamics; Neurological disorder; Ergometry
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1999.86.3.806

1  Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, DK-2400 Copenhagen NV; Departments of 2  Anesthesia and 3  Internal Medicine TTA, Copenhagen Muscle Research Center, Rigshospitalet, DK-2100 Copenhagen; and 4  Department of Medical Physiology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, Denmark Feed-forward and feedback mechanisms are both important for control of the heart rate response to muscular exercise, but their origin and relative importance remain inadequately understood. To evaluate whether humoral mechanisms are of importance, the heart rate response to electrically induced cycling was studied in participants with spinal cord injury (SCI) and compared with that elicited during volitional cycling in able-bodied persons (C). During voluntary exercise at an oxygen uptake of ~1 l/min, heart rate increased from 66 ± 4 to 86 ± 4 (SE) beats/min in seven C, and during electrically induced exercise at a similar oxygen uptake in SCI it increased from 73 ± 3 to 110 ± 8 beats/min. In contrast, blood pressure increased only in C (from 88 ± 3 to 99   ± 4 mmHg), confirming that, during exercise, blood pressure control is dominated by peripheral neural feedback mechanisms. With vascular occlusion of the legs, the exercise-induced increase in heart rate was reduced or even eliminated in the electrically stimulated SCI. For C, heart rate tended to be lower than during exercise with free circulation to the legs. Release of the cuff elevated heart rate only in SCI. These data suggest that humoral feedback is of importance for the heart rate response to exercise and especially so when influence from the central nervous system and peripheral neural feedback from the working muscles are impaired or eliminated during electrically induced exercise in individuals with SCI. blood pressure; feedback mechanism; central command Deceased.