Gold nanoparticles for the colorimetric and fluorescent detection of ions and small organic molecules

In recent years, gold nanoparticles (AuNPs) have drawn considerable research attention in the fields of catalysis, drug delivery, imaging, diagnostics, therapy and biosensors due to their unique optical and electronic properties. In this review, we summarized recent advances in the development of Au...

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Bibliographic Details
Published inNanoscale Vol. 3; no. 4; pp. 1421 - 1433
Main Authors Liu, Dingbin, Wang, Zhuo, Jiang, Xingyu
Format Journal Article
LanguageEnglish
Published England 01.01.2011
Subjects
Assaying
Biosensors
Cations
Colorimetry
Colorimetry - methods
Drug delivery systems
Gold
Gold - chemistry
Molecular Probe Techniques
Nanoparticles
Nanostructure
Nanostructures - chemistry
Nanostructures - ultrastructure
Organic Chemicals - analysis
Organic Chemicals - chemistry
Spectrometry, Fluorescence - methods
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Summary:In recent years, gold nanoparticles (AuNPs) have drawn considerable research attention in the fields of catalysis, drug delivery, imaging, diagnostics, therapy and biosensors due to their unique optical and electronic properties. In this review, we summarized recent advances in the development of AuNP-based colorimetric and fluorescent assays for ions including cations (such as Hg 2+ , Cu 2+ , Pb 2+ , As 3+ , Ca 2+ , Al 3+ , etc ) and anions (such as NO 2 − , CN − , PF 6 − , F − , I − , oxoanions), and small organic molecules (such as cysteine, homocysteine, trinitrotoluene, melamine and cocaine, ATP, glucose, dopamine and so forth). Many of these species adversely affect human health and the environment. Moreover, we paid particular attention to AuNP-based colorimetric and fluorescent assays in practical applications. We review recent advances in the development of AuNP-based colorimetric and fluorescent assays for ions and small organic molecules.
Bibliography:Zhuo Wang received her MS from the Northeast Normal University (P. R. China) in 2003 and her PhD in Organic Chemistry from the Institute of Chemistry, Chinese Academy of Sciences in 2006. After two years of postdoctoral research at Bowling Green State University (USA), she joined the NCNST as an assistant professor. Her research interests focus on the synthesis and modification of nanoparticles, and the biochemical assays based on small organic molecules and nanomaterials.
Xingyu Jiang is a Professor in the National Center for NanoScience and Technology of China (NCNST). His research interests include surface chemistry, microfluidics, micro/nano-fabrication, cell biology and immunoassays. He obtained his BS at The University of Chicago (1999), followed by an AM (2001) and a PhD (2004) from Harvard University (Chemistry), working with Professor George Whitesides. After a postdoctoral fellowship with Professor Whitesides, he joined NCNST in 2005.
Dingbin Liu is currently a PhD candidate at NCNST under the supervision of Prof. Xingyu Jiang. He received his BS from Lanzhou University in 2006 and MS from Chengdu Institute of Biology, Chinese Academy of Sciences in 2009. His current research interest is the design of gold nanoparticles (AuNPs) for ultrasensitive detection of biomolecules. He is also interested in the construction of AuNP-based drug delivery systems.
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ISSN:2040-3364
2040-3372
DOI:10.1039/c0nr00887g