Acylated cholestane glycosides from the bulbs of Ornithogalum saundersiae

• Published in: Phytochemistry (Oxford) Vol. 31; no. 11; pp. 3969 - 3973
• Main Authors: Kubo, Satoshi, Mimaki, Yoshihiro, Terao, Miki, Sashida, Yutaka, Nikaido, Tamotsu, Ohmoto, Taichi
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 1992; Elsevier
• Subjects: acylated cholestane glycosides; Biochemistry & Molecular Biology; Biological and medical sciences; bulbs; chemical constituents of plants; Chemical constitution; cyclic AMP; cyclic AMP phosphodiesterase; enzyme inhibitors; Fundamental and applied biological sciences. Psychology; glycosides; inhibitory activity; Life Sciences & Biomedicine; Liliaceae; molecular conformation; Ornithogalum; Ornithogalum saundersiae; phosphodiesterase I; Plant physiology and development; Plant Sciences; Schilloideae; Science & Technology; spectral analysis; Schilloideae; bulbs; Liliaceae; Ornithogalum saundersiae; cyclic AMP phosphodiesterase; inhibitory activity; acylated cholestane glycosides; INHIBITORY ACTIVITY; ORNITHOGALUM-SAUNDERSIAE; BULBS; CYCLIC-AMP PHOSPHODIESTERASE; CYCLIC AMP PHOSPHODIESTERASE; SCHILLOIDEAE; LILIACEAE; ACYLATED CHOLESTANE GLYCOSIDES; Monocotyledones; Molecular structure; Bulb; Angiospermae; Isolation; Spermatophyta; Cholestane derivatives; Glycoside
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/S0031-9422(00)97565-4

Phytochemical examination of the bulbs of Ornithogalum saundersiae led to the isolation of three new acylated cholestane glycosides. Their structures were elucidated, on the basis of the spectroscopic data and chemical evidences, and by comparing them with those of known compounds, as 3βP,16βP,17α-trihydroxycholest-5-en-22-one 16- O-β- d-xylopyranosyl-(1→3)-(2- O-acetyl-α- l-arabinopyranoside), 3β,16β,17α-trihydroxycholest-5-en-22-one 16- O-(2- O-4-methoxybenzoyl-βP- d-xylopyranosyl)-(1→3)-(2- O-acetyl-α- l-arabinopyranoside) and 3β,16β,17α-trihydroxy-cholest-5-en-22-one 16- O-(2- O-3,4-dimethoxybenzoyl-β- d-xylopyranosyl)-(1→3)-(2- O-acetyl-α- l-arabinopyranoside). Inhibitory activity on cyclic AMP phosphodiesterase of the cholestane glycosides was evaluated.