Postprandial effects on electrolyte homeostasis in the kidney

Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes an...

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Published inAmerican journal of physiology. Renal physiology Vol. 317; no. 6; pp. F1405 - F1408
Main Authors Klemens, Christine A, Brands, Michael W, Staruschenko, Alexander
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.12.2019
Subjects
Animals
Diabetes mellitus
Homeostasis
Homeostasis - physiology
Humans
Insulin
Kidney - metabolism
Kidney - physiology
Kidneys
Postprandial Period - physiology
Reabsorption
Renal function
Review
Sodium
Sodium channels
Water-Electrolyte Balance - physiology
glucose
fasting
insulin
epithelial Na+ channel
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Summary:Insulin is known to be an important regulator of a number of different channels and transporters in the kidney, but its role in the kidney to prevent Na and volume loss during the osmotic load after a meal has only recently been validated. With increasing numbers of people suffering from diabetes and hypertension, furthering our understanding of insulin signaling and renal Na handling in both normal and diseased states is essential for improving patient treatments and outcomes. The present review is focused on postprandial effects on Na reabsorption in the kidney and the role of the epithelial Na channels as an important channel contributing to insulin-mediated Na reclamation.
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ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00350.2019