HUMAN INFECTION AND RISK OF TRANSMISSION OF CHAGAS DISEASE IN HIDALGO STATE, MEXICO

• Published in: The American journal of tropical medicine and hygiene Vol. 76; no. 2; pp. 318 - 323
• Main Authors: BECERRIL-FLORES, MARCO A, RANGEL-FLORES, EDUARDO, LUIS IMBERT-PALAFOX, JOSE, GOMEZ-GOMEZ, JUAN VICENTE, FIGUEROA-GUTIERREZ, ANA HILDA
• Format: Journal Article
• Language: English
• Published: Lawrence, KS ASTMH 01.02.2007; Allen Press
• Subjects: Adolescent; Adult; Animals; Antibodies, Protozoan - blood; Biological and medical sciences; Chagas Disease - epidemiology; Chagas Disease - parasitology; Chagas Disease - transmission; Child; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Female; Hemagglutination Tests; Human protozoal diseases; Humans; Infectious diseases; Insect Vectors - parasitology; Male; Medical sciences; Mexico - epidemiology; Mice; Mice, Inbred BALB C; Middle Aged; Parasitemia - parasitology; Parasitic diseases; Protozoal diseases; Seroepidemiologic Studies; Triatoma; Triatoma dimidiata; Triatominae - parasitology; Trypanosoma cruzi; Trypanosoma cruzi - isolation & purification; Trypanosoma cruzi - pathogenicity; Trypanosomiasis; Virulence; Central America; Mexico; America; Mexico, Hidalgo; Chile, Atacama, San Antonio; Infection; Human; Protozoal disease; Risk factor; Chagas disease; Tropical medicine; Parasitosis; Trypanosomiasis; Epidemiology; Public health
• ISSN: 0002-9637; 1476-1645
• DOI: 10.4269/ajtmh.2007.76.318

New zones with risk of infection for Chagas disease were reported in San Antonio Tezoquipan, Caltimacan, and El Ahorcado in the Hidalgo State of Mexico. Antibodies to Trypanosoma cruzi were detected by enzyme-linked immunosorbent assay and indirect hemagglutination assay in human serum samples. Study subjects were also given an electrocardiogram. Trypanosoma cruzi was isolated from triatomines collected and its virulence was determined in BALB/c mice. Seropositive persons were found in the three regions studied and seroprevalence of T. cruzi ranged between 3.25% and 5.13%. Six of eight seropositive persons had cardiac alterations. The species of triatomines detected were Triatoma barberi, Triatoma mexicana, and Triatoma dimidiata, and at least one of each species was infected with T. cruzi. Entomologic indexes from the zones were determined, and El Ahorcado showed the greatest risk of infection. In this region, we found more virulent isolates of T. cruzi in Triatoma barberi, and the highest human seroprevalence for T. cruzi.