Factor Xa inhibitors by classical and combinatorial chemistry

A high-priority goal in the search for new antithrombotic agents is the identification of small-molecule compounds that selectively inhibit the blood coagulation Factor Xa. These compounds should limit blood loss while controlling thrombosis following surgery, heart attacks, infection by Gram-negati...

Full description

Saved in:
Bibliographic Details
Published inDrug discovery today Vol. 3; no. 5; pp. 223 - 231
Main Authors Al-Obeidi, Fahad, Ostrem, James A
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.05.1998
Elsevier Science
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:A high-priority goal in the search for new antithrombotic agents is the identification of small-molecule compounds that selectively inhibit the blood coagulation Factor Xa. These compounds should limit blood loss while controlling thrombosis following surgery, heart attacks, infection by Gram-negative organisms, and other coagulation disorders. Three naturally occurring small proteins (antistasin, tick anticoagulant peptide and yagin) and a diverse collection of small-molecule inhibitors of Factor Xa, originating from both structure-based design and screening of historical compounds and combinatorial libraries, have been described. This review summarizes recent entries into preclinical research, including a series of unique Factor Xa inhibitors recently uncovered in combinatorial peptide libraries.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(97)01165-3