Recent discovery of plant-derived anti-diabetic natural products
Covering: 2005 to 2010 This review covers recent discoveries of anti-diabetic compounds. Diabetes mellitus (DM) is a complex disease affecting patients' daily life and elevating patients' risk of developing other diseases. There are several forms of diabetes, including type-1 diabetes (ins...
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| Published in | Natural product reports Vol. 29; no. 5; pp. 58 - 66 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.05.2012
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Covering: 2005 to 2010
This review covers recent discoveries of anti-diabetic compounds. Diabetes mellitus (DM) is a complex disease affecting patients' daily life and elevating patients' risk of developing other diseases. There are several forms of diabetes, including type-1 diabetes (insulin-dependent), type-2 diabetes (noninsulin-dependent), and gestational diabetes. Type-2 diabetes is the most common form and the patient population with type-2 DM rises every year. Current treatments meet some but not all patients' needs. Therefore, new anti-diabetic drugs are in great demand. Traditional herbal medicine provides a rich source for new drug discovery. In this review, recent discoveries of anti-diabetic compounds have been summarized according to their chemical structures and mechanisms of action. Anti-diabetic plant extracts, many of which have been used and marketed as dietary supplements, were also included and discussed, and are classified according to the positive control used in the anti-diabetic animal studies. New anti-diabetic natural products found in the recent patent literature are also summarized.
Recent discoveries of plant-derived anti-diabetic natural products, plant extracts, and patent literature are reviewed. As examples, two acylated kaempferol compounds (
2
,
3
) exhibited significant -glucosidase inhibition, and two quassinoids (
4
,
5
) showed comparable blood sugar lowering effects
in vivo
with glibenclamide. |
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| Bibliography: | (1986, OHAI press). Keduo Qian received her B.S. degree in Pharmacy from Beijing University in 2004, and her Ph.D. degree in Pharmaceutical Sciences from the University of North Carolina at Chapel Hill (UNC-CH) in 2008. She became Research Assistant Professor in the Division of Chemical Biology and Medicinal Chemistry, UNC-CH in 2009. Her research interests include the design and synthesis of bioactive compounds, development of analytical methods, as well as drug metabolism and pharmacokinetics (DMPK) evaluation. Kuo-Hsiung Lee received his B.S. in pharmacy from Kaohsiung Medical University, Taiwan (1961), M.S. in pharmaceutical chemistry from Kyoto University, Japan (1965), and Ph.D. in medicinal chemistry from University of Minnesota, Minneapolis (1968). He joined the faculty of UNC Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, in 1970 and is now Kenan Distinguished Professor of Medicinal Chemistry and Director of the Natural Products Research Laboratories. He has published over 730 research articles, been granted over 76 patents, and received numerous awards, including most recently, the Order of the Rising Sun, Gold Rays with Neck Ribbon, from the Government of Japan. Commonly Used Chinese Herb Formulas with Illustrations Susan L. Morris-Natschke received her B.S. in chemistry from the University of Maryland-College Park in 1975 and her Ph.D. in organic chemistry from the University of North Carolina-Chapel Hill (UNC-CH) in 1982. She is currently Research Professor in the Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, UNC-CH, where she has been on the faculty since 1983. Her interests include scientific writing/editing, as well as the synthesis and structureactivity relationships of bioactive natural products. (1980, OHAI press) and Chau-shin Hsu received his B.S. in Pharmacy from Taipei Medical College, Taiwan (1967), and his M.S. and Ph.D. degrees in Pharmaceutical Chemistry from Tokyo College of Pharmacy, Japan (1972 and 1975, respectively). He served as R&D Director, Plant Manager, and Vice President of Sun Ten Pharmaceutical Co., Taipei, Taiwan, from 1979 to 1989, where he is now Chairman. He was also a former President and Chairman of Sun Ten Laboratories, Inc., Irvine, California (1991 to 2005). He is the author of Oriental Materia Medica Hsin-Yi Hung received her B.S. and M.S. degrees in Pharmaceutical Science from National Taiwan University (2003 and 2005, respectively). She is currently a predoctoral student in the Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Her research interests include the isolation, structural elucidation, and structural modification of bioactive natural products for both anti-cancer and anti-HIV effects. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Review-3 |
| ISSN: | 0265-0568 1460-4752 1460-4752 |
| DOI: | 10.1039/c2np00074a |