A trehalose ester from Lancea tibetica

A phytochemical study of the 95% ethanolic extract of the whole plant of Lancea tibetica Hook. f. et Thoms. led to the isolation of a new trehalose ester, 6-O-undecanoyl-α,β-trehalose (1), along with 23 known compounds (2-24), of which compounds 2-17 were isolated from this plant for the first time....

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Published inNatural product research Vol. 28; no. 19; pp. 1613 - 1618
Main Authors Liu, Shi-Jun, Liao, Zhi-Xin, Liu, Chao, Qu, Yan-Bo
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2014
Subjects
anti-tumour activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Cell Proliferation - drug effects
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Female
flavone
Hep G2 Cells
Humans
Lancea tibetica
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Trehalose - analogs & derivatives
Trehalose - chemistry
Trehalose - isolation & purification
Trehalose - pharmacology
trehalose ester
triterpenoid
triterpenoid
trehalose ester
anti-tumour activity
Lancea tibetica
flavone
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Summary:A phytochemical study of the 95% ethanolic extract of the whole plant of Lancea tibetica Hook. f. et Thoms. led to the isolation of a new trehalose ester, 6-O-undecanoyl-α,β-trehalose (1), along with 23 known compounds (2-24), of which compounds 2-17 were isolated from this plant for the first time. The structures of these compounds were established on the basis of spectroscopic methods. Compound 1 was evaluated for their in vitro anti-proliferative activities against MCF-7, NCI-H460 and Hep-G2 tumour cell lines. Compound 1 exhibited potent inhibitory activity against NCI-H460 cell growth, in contrast to moderate cytotoxic activity against MCF-7 and Hep-G2 cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2014.930859