New Evidence and Perspectives on the Management of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Portal vein tumor thrombosis (PVTT) is an intractable condition but common phenomenon in hepatocellular carcinoma (HCC). HCC patients with PVTT may have worse liver function, a higher chance of comorbidity related to portal hypertension, lower tolerance to treatment and poorer prognoses. In Western...

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Published inJournal of clinical and translational hepatology Vol. 5; no. 2; pp. 169 - 176
Main Authors Yin, Jun, Bo, Wen-Tao, Sun, Jian, Xiang, Xiao, Lang, Jin-Yi, Zhong, Jian-Hong, Li, Le-Qun
Format Journal Article
LanguageEnglish
Published China Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China%Department of Hepatobiliary Surgery, Sichuan Cancer Hospital &Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China%Department of Medical Affairs, ZiBo Hospital of Integrated Traditional Chinese and Western Medicine, Zibo, China%Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China 28.06.2017
XIA & HE Publishing Inc
Subjects
Review
Portal vein tumor thrombosis
Hepatocellular carcinoma
Transarterial chemoembolization
Hepatic resection
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Summary:Portal vein tumor thrombosis (PVTT) is an intractable condition but common phenomenon in hepatocellular carcinoma (HCC). HCC patients with PVTT may have worse liver function, a higher chance of comorbidity related to portal hypertension, lower tolerance to treatment and poorer prognoses. In Western guidelines, patients are offered palliative treatment with sorafenib or other systemic agents because HCC with PVTT is grouped together with metastatic HCC during the planning of its management. In recent years, various treatment options have become available for patients with HCC and PVTT. Therapy has also shifted toward evidence-based treatment. However, policies for the management of HCC with PVTT have not been established. This comprehensive literature review aims to present current and available management options for patients with HCC and PVTT. Evidence is mainly based on studies published after 2010.
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These two authors contributed equally to this work
Manuscript design (JHZ), manuscript writing (JY, WTB, JS, XX, JYL, LQL, JHZ), final approval (JHZ).
The authors have no conflict of interests related to this publication.
ISSN:2225-0719
2310-8819
DOI:10.14218/JCTH.2016.00071