Oral antioxidants improve leg blood flow during exercise in patients with chronic obstructive pulmonary disease

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 309; no. 5; pp. H977 - H985
• Main Authors: Rossman, Matthew J., Trinity, Joel D., Garten, Ryan S., Ives, Stephen J., Conklin, Jamie D., Barrett-O'Keefe, Zachary, Witman, Melissa A. H., Bledsoe, Amber D., Morgan, David E., Runnels, Sean, Reese, Van R., Zhao, Jia, Amann, Markus, Wray, D. Walter, Richardson, Russell S.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.09.2015
• Subjects: Administration, Oral; Aged; Antioxidants - administration & dosage; Antioxidants - therapeutic use; Blood pressure; Chronic obstructive pulmonary disease; Exercise; Female; Human subjects; Humans; Integrative Cardiovascular Physiology and Pathophysiology; Leg - blood supply; Male; Middle Aged; Oxidative stress; Oxygen; Physiology; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - physiopathology; Regional Blood Flow; Veins & arteries; oxygen transport; exercise; chronic bronchitis; oxidative stress; chronic obstructive pulmonary disease; emphysema

The consequence of elevated oxidative stress on exercising skeletal muscle blood flow as well as the transport and utilization of O 2 in patients with chronic obstructive pulmonary disease (COPD) is not well understood. The present study examined the impact of an oral antioxidant cocktail (AOC) on l...