Convenient synthesis of heterobifunctional poly(ethylene glycol) suitable for the functionalization of iron oxide nanoparticles for biomedical applications

A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The su...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 23; no. 17; pp. 5006 - 5010
Main Authors Passemard, Solène, Staedler, Davide, Učňová, Lucia, Schneiter, Guillaume Stéphane, Kong, Phally, Bonacina, Luigi, Juillerat-Jeanneret, Lucienne, Gerber-Lemaire, Sandrine
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.09.2013
Elsevier
Subjects
Cancer cells targeting
Cell Line, Tumor
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Dextrans - adverse effects
Dextrans - chemistry
Erythrocytes - cytology
Erythrocytes - drug effects
Functionalized nanoparticles
Heavy metals
Hemolysis - drug effects
Heterotelechelic PEG oligomer
Humans
Life Sciences & Biomedicine
Magnetite Nanoparticles - adverse effects
Magnetite Nanoparticles - chemistry
Neoplasms - diagnosis
Oligopeptides - chemistry
Pegylation
Pharmacology & Pharmacy
Physical Sciences
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
Science & Technology
Selective monoreduction
USPIO NPs
Cancer cells targeting
Selective monoreduction
Functionalized nanoparticles
Heterotelechelic PEG oligomer
Pegylation
USPIO NPs
GOLD NANOPARTICLES
SURFACE FUNCTIONALIZATION
ONE END
CYCLIC RGD PEPTIDE
ENHANCED TRANSFECTION
TUMOR
MAGNETIC NANOPARTICLES
CANCER
ALPHA(V)BETA INTEGRIN
LIGANDS
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Summary:A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The suitability of these PEG derivatives to be conjugated to nanomaterials was shown by pegylation of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles (NPs), followed by functionalization with small peptide ligands for biomedical applications.
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ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2013.06.037