Structure and hypolipidaemic activity of fucoidan extracted from brown seaweed Sargassum henslowianum

• Published in: Natural product research Vol. 29; no. 5; pp. 411 - 415
• Main Authors: Cuong, Ho Duc, Thuy, Thanh Thi Thu, Huong, Tran Thu, Ly, Bui Minh, Van, Tran Thi Thanh
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.03.2015
• Subjects: Animals; brown seaweed Sargassum henslowianum; Fucoidan; hypolipidaemic activity; Hypolipidemic Agents - chemistry; Hypolipidemic Agents - pharmacology; Mice, Inbred BALB C; Polysaccharides - chemistry; Polysaccharides - pharmacology; Sargassum - chemistry; Seaweed - chemistry; Spectrometry, Mass, Electrospray Ionization; structure; Vietnam; Vietnam; brown seaweed Sargassum henslowianum; hypolipidaemic activity; Fucoidan; structure
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2014.948436

The aim of this study is to elucidate the structure and investigate the hypolipidaemic activity of a fucoidan extracted from brown seaweed Sargassum henslowianum collected at Hai Van-Son Cha peninsula, Hue province, Vietnam by using tandem electrospray ionisation mass spectrometry. The results demonstrated that the fucoidan has α(1 → 3)-linked l-fucopyranose backbone and sulphate groups occupied mostly at C-2, C-4 and sometimes at C-3 position of fucose residues. The results of in vivo bioactivity examination revealed that the fucoidan in the dose of 100 mg/kgP/day by oral administration helped decrease cholesterol, triglyceride and LDL-cholesterol levels on obese mice.