Association of GCKR Gene Polymorphisms with the Risk of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in a Chinese Northern Han Population

• Published in: Journal of clinical and translational hepatology Vol. 7; no. 4; pp. 297 - 303
• Main Authors: Gao, Hui, Liu, Shousheng, Zhao, Zhenzhen, Yu, Xinjuan, Liu, Qun, Xin, Yongning, Xuan, Shiying
• Format: Journal Article
• Language: English
• Published: China Department of Gastroenterology,Qingdao Municipal Hospital,Qingdao University,Qingdao,Shandong,China 28.12.2019; Digestive Disease Key Laboratory of Qingdao,Qingdao,Shandong,China; Department of Infectious Disease,Qingdao Municipal Hospital,Qingdao University,Qingdao,Shandong,China%Central Laboratories,Qingdao Municipal Hospital,Qingdao University,Qingdao,Shandong,China; Digestive Disease Key Laboratory of Qingdao,Qingdao,Shandong,China%Central Laboratories,Qingdao Municipal Hospital,Qingdao University,Qingdao,Shandong,China%Department of Infectious Disease,Qingdao Municipal Hospital,Qingdao University,Qingdao,Shandong,China; XIA & HE Publishing Inc
• Subjects: Original; Glucokinase regulatory protein gene; Non-alcoholic fatty liver disease; Coronary artery disease; Polymorphism
• ISSN: 2225-0719; 2310-8819
• DOI: 10.14218/JCTH.2019.00030

Accumulated studies have evaluated the effects of glucokinase regulatory protein ( ) gene polymorphisms on the risk of nonalcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD), but the association of polymorphisms with the risk of NAFLD and CAD in the Chinese Han population have remained unclear. The aim of this study was to investigate the association between gene polymorphisms (rs780094 and rs1260326) and the risk of NAFLD and CAD in NAFLD patients in a Chinese Northern Han population. rs780094 and rs1260326 gene polymorphisms were genotyped by polymerase chain reaction sequencing for B-type ultrasonography-proven NAFLD patients with ( = 82) or without ( = 142) CAD, and in healthy controls ( = 152). Serum lipid profiles' levels were determined using biochemical methods. Statistical analyses were conducted using SPSS 22.0 statistical software. As the results showed, significant differences in the serum lipid profiles existed between each group. No significant differences were observed in the distributions of genotypes and alleles of rs780094 and rs1260326 in each group. The rs780094 T and rs1260326 T allele carriers possessed decreased body mass index value, and serum fasting plasma glucose and TG levels in the overall subjects, respectively. In addition, the rs780094 T allele carriers possessed decreased serum fasting plasma glucose level in the controls and NAFLD + CAD patients. rs780094 and rs1260326 polymorphisms were found to be not associated with the risk of NAFLD nor of CAD in NAFLD patients in this Chinese Northern Han population. rs780094 T and rs1260326 T alleles could affect the body mass index value and serum fasting plasma glucose and triglyceride levels.