A novel antimicrobial agent from the leaves of Peltophorum vogelianum (Benth.)

• Published in: Natural product research Vol. 24; no. 13; pp. 1268 - 1273
• Main Authors: Parveen, Mehtab, Ghalib, Raza Murad, Khanam, Zakia, Mehdi, Sayed Hasan, Ali, Mohammed
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 01.08.2010
• Subjects: 1-pentatriacontanol; Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; antimicrobial activity; Bacteria - drug effects; Caesalpiniaceae; Chromatography, Gel; Crystallization; Fabaceae - chemistry; friedelin; India; Mass Spectrometry; Methanol; Microbial Sensitivity Tests; Molecular Structure; Peltophorum; Peltophorum vogelianum; peltophorumyl β-D-glucuropyranoside; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Leaves - chemistry; Plants, Medicinal - chemistry; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; β-sitosterol; β-sitosterol-β-D-glucopyranoside; India
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786410903387688

The methanolic extract of the leaves of Peltophorum vogelianum (Caesalpiniaceae) afforded a new phytoconstituent, 2-methoxy-4,5-dihydroxy-1(7,8-dihydroxyethylene)-8-β-D-glucuropyranoside named as peltophorumyl-β-D-glucuropyranoside (5), along with four known phytoconstituents, 1-pentatriacontanol (1), friedelin (2), β-sitosterol (3) and β-sitosterol-β-D-glucopyranoside (4), which have not been isolated previously from this plant. Their structures were established on the basis of chemical and physical evidence (IR, 1 H-NMR, 13 C-NMR, DEPT, HSQC, HMBC and MS). Moreover, compound 5 showed significant antimicrobial activity.