First synthesis of novel 3,3′-bipyridazine derivatives as new potent antihepatocellular carcinoma agents

• Published in: Tetrahedron Vol. 71; no. 40; pp. 7670 - 7675
• Main Authors: Yue, Qiming, Zhao, Yi, Hai, Li, Zhang, Tao, Guo, Li, Wu, Yong
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 07.10.2015; Elsevier
• Subjects: 3,3′-Bipyridazine derivatives; Activity; anti-Hepatoma; Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; Synthesis; anti-Hepatoma; Activity; Synthesis; 3,3′-Bipyridazine derivatives; HEPATOCELLULAR-CARCINOMA; LIVER-TRANSPLANTATION; PYRIDAZINES; 3,3 '-Bipyridazine derivatives

Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YH...