First synthesis of novel 3,3′-bipyridazine derivatives as new potent antihepatocellular carcinoma agents
Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YH...
Saved in:
Published in | Tetrahedron Vol. 71; no. 40; pp. 7670 - 7675 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
07.10.2015
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YHHU-759 as the leading compound for reasonable structure modification, a series of 3,3′-bipyridazine derivatives including 8 novel compounds in this study were designed, synthesized and screened for their anti-hepatoma activities against liver cancer cell lines SMMC-7721, BEL-7402 and QGY-7703 in vitro. The result shows that all of the 3,3′-bipyridazine derivatives have good anti-hepatoma activities.
[Display omitted] |
---|---|
ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2015.07.063 |