First synthesis of novel 3,3′-bipyridazine derivatives as new potent antihepatocellular carcinoma agents
Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YH...
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| Published in | Tetrahedron Vol. 71; no. 40; pp. 7670 - 7675 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
OXFORD
Elsevier Ltd
07.10.2015
Elsevier |
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| Abstract | Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YHHU-759 as the leading compound for reasonable structure modification, a series of 3,3′-bipyridazine derivatives including 8 novel compounds in this study were designed, synthesized and screened for their anti-hepatoma activities against liver cancer cell lines SMMC-7721, BEL-7402 and QGY-7703 in vitro. The result shows that all of the 3,3′-bipyridazine derivatives have good anti-hepatoma activities.
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| AbstractList | Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YHHU-759 as the leading compound for reasonable structure modification, a series of 3,3′-bipyridazine derivatives including 8 novel compounds in this study were designed, synthesized and screened for their anti-hepatoma activities against liver cancer cell lines SMMC-7721, BEL-7402 and QGY-7703 in vitro. The result shows that all of the 3,3′-bipyridazine derivatives have good anti-hepatoma activities.
[Display omitted] Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YHHU-759 as the leading compound for reasonable structure modification, a series of 3,3'-bipyridazine derivatives including 8 novel compounds in this study were designed, synthesized and screened for their ann-hepatoma activities against liver cancer cell lines SMMC-7721, BEL-7402 and QGY-7703 in vitro. The result shows that all of the 3,3'-bipyridazine derivatives have good anti-hepatoma activities. (C) 2015 Elsevier Ltd. All rights reserved. |
| Author | Guo, Li Wu, Yong Zhao, Yi Hai, Li Yue, Qiming Zhang, Tao |
| Author_xml | – sequence: 1 givenname: Qiming surname: Yue fullname: Yue, Qiming organization: Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China – sequence: 2 givenname: Yi surname: Zhao fullname: Zhao, Yi organization: Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China – sequence: 3 givenname: Li surname: Hai fullname: Hai, Li organization: Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China – sequence: 4 givenname: Tao surname: Zhang fullname: Zhang, Tao organization: ChengDu Military General Hospital, Chengdu 610083, PR China – sequence: 5 givenname: Li surname: Guo fullname: Guo, Li email: guoli@scu.edu.cn organization: Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China – sequence: 6 givenname: Yong orcidid: 0000-0003-0719-4963 surname: Wu fullname: Wu, Yong email: wyong@scu.edu.cn organization: Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China |
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| CitedBy_id | crossref_primary_10_1248_cpb_c17_00918 crossref_primary_10_1039_D2GC01199A crossref_primary_10_1016_j_ejmech_2019_02_015 crossref_primary_10_1002_chin_201602155 crossref_primary_10_1002_jhet_4589 crossref_primary_10_3390_molecules22010148 crossref_primary_10_1007_s11094_023_02876_3 crossref_primary_10_1016_j_ejmech_2016_07_061 crossref_primary_10_1007_s00044_021_02782_x |
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| Keywords | anti-Hepatoma Activity Synthesis 3,3′-Bipyridazine derivatives HEPATOCELLULAR-CARCINOMA LIVER-TRANSPLANTATION PYRIDAZINES 3,3 '-Bipyridazine derivatives |
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| SubjectTerms | 3,3′-Bipyridazine derivatives Activity anti-Hepatoma Chemistry Chemistry, Organic Physical Sciences Science & Technology Synthesis |
| Title | First synthesis of novel 3,3′-bipyridazine derivatives as new potent antihepatocellular carcinoma agents |
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