Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 22; no. 2; pp. 174 - 178
• Main Authors: Saito, Shinichiro, Takeshita, Masao, Tomonobu, Kazuichi, Kudo, Naoto, Shiiba, Daisuke, Hase, Tadashi, Tokimitsu, Ichiro, Yasukawa, Takuji
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2006; Elsevier; Elsevier Limited
• Subjects: Adult; Anticholesteremic Agents - administration & dosage; Anticholesteremic Agents - therapeutic use; Biological and medical sciences; blood lipids; cholesteremic effect; Cholesterol; Cholesterol - blood; cholesterol metabolism; Cholesterol, HDL - blood; Cholesterol, LDL - blood; cholesteryl esters; Diacylglycerol; diacylglycerols; Diet; Diglycerides - therapeutic use; Dose-Response Relationship, Drug; Double-Blind Method; Esters; Feeding. Feeding behavior; food intake; Fundamental and applied biological sciences. Psychology; high density lipoprotein; Humans; hypercholesterolemia; Hypercholesterolemia - diet therapy; Ingestion; Low density lipoprotein; Male; Mayonnaise; men; phytosterols; Phytosterols - therapeutic use; Plant sterol esters; Studies; Treatment Outcome; Triacylglycerol; triacylglycerols; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Japan; Plant sterol esters; Mayonnaise; Triacylglycerol; Cholesterol; Diacylglycerol; Diglyceride; Lipids; Ester; Vertebrata; Plant; Mammalia; Dose; Sterol
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2005.05.013

The objective of this study was to investigate the effective dose of plant sterol ester (PSE)-enriched diacylglycerol (DAG) oil for healthy subjects with mild hypercholesterolemia. A randomized, placebo-controlled, double-blind, parallel study was performed in patients with mild hypercholesterolemia; 0.0, 0.3, 0.4, and 0.5 g of PSE was dissolved in 15 g of a DAG-containing mayonnaise-type product; and 15 g/d of the product was administered 4 wk. Total serum cholesterol levels were significantly decreased as a result of the ingestion of at least 0.4 g/d of PSE, and serum low-density lipoprotein cholesterol levels were significantly decreased by the ingestion of at least 0.3 g/d of PSE. Daily ingestion of 15 g of DAG plus mayonnaise containing at least 0.4 g/d of PSE for 4 wk may significantly decrease cholesterol.