Confronting the challenges of discovery of novel antibacterial agents

This article looks at the historical as well as current status of antibacterial discovery with a broad viewpoint and provides some perspective as how to address some of the challenges. [Display omitted] Bacterial resistance is inevitable and is a growing concern. It can be addressed only by discover...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 24; no. 16; pp. 3683 - 3689
Main Author Singh, Sheo B.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 15.08.2014
Subjects
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial
Antimicrobial
Bacteria - drug effects
Discovery strategy
Drug Discovery
Humans
Microbial Sensitivity Tests
Molecular Structure
Phenotypic screening
Topoisomerase II
Antimicrobial
Antibacterial
Phenotypic screening
Discovery strategy
Topoisomerase II
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Summary:This article looks at the historical as well as current status of antibacterial discovery with a broad viewpoint and provides some perspective as how to address some of the challenges. [Display omitted] Bacterial resistance is inevitable and is a growing concern. It can be addressed only by discovery and development of new agents. However the discovery and development of new antibacterial agents are at an all time low. This article broadly examines the historical as well as current status of antibacterial discovery and provides some perspective as how to address some of the challenges.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2014.06.053