Case Report: SMARCA4 (BRG1)-deficient undifferentiated carcinoma of gallbladder with genetic analysis

-deficient undifferentiated carcinoma is a rare and highly aggressive malignancy. It has been reported to occur in a multiple range of organs. However, to the best of our knowledge, -deficient undifferentiated carcinoma of gallbladder has not yet been reported. Here, we describe a case of -deficient...

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Published inFrontiers in oncology Vol. 13; p. 1086266
Main Authors Meng, Xiangpeng, Ma, Jia, Meng, Nan, Yun, Tianyu, Niu, Beifang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 30.06.2023
Subjects
BRG1
case report
gallbladder carcinoma
Oncology
SMARCA4
SWI/SNF
case report
gallbladder carcinoma
BRG1
SWI/SNF
SMARCA4
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Summary:-deficient undifferentiated carcinoma is a rare and highly aggressive malignancy. It has been reported to occur in a multiple range of organs. However, to the best of our knowledge, -deficient undifferentiated carcinoma of gallbladder has not yet been reported. Here, we describe a case of -deficient undifferentiated carcinoma of gallbladder. Through comprehensive genetic analysis, we hypothesized that in addition to deficiency, other genetic changes might also be involved in the tumorigenesis of undifferentiated gallbladder cancer in this patient, particularly somatic mutations in the , and genes. To the best of our knowledge, this is the first report of -deficient undifferentiated carcinoma of gallbladder with genetic analysis.
Bibliography:These authors have contributed equally to this work
Reviewed by: Patricia N. Tonin, McGill University, Canada; Bingcheng Wu, National University Hospital, Singapore
Edited by: Satvinder Singh Mudan, The London Clinic, United Kingdom
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1086266