A comparison of the endocrine effects of low dose aminoglutethimide with and without hydrocortisone in postmenopausal breast cancer patients

The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populati...

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Published inBritish journal of cancer Vol. 52; no. 4; pp. 525 - 529
Main Authors DOWSETT, M, HARRIS, A. L, STUART-HARRIS, R, HILL, M, CANTWELL, B. M. J, SMITH, I. E, JEFFCOATE, S. L
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.10.1985
Subjects
Adult
Aged
Aminoglutethimide - administration & dosage
Aminoglutethimide - therapeutic use
Androstenedione - blood
Biological and medical sciences
Breast Neoplasms - blood
Breast Neoplasms - drug therapy
Dehydroepiandrosterone - analogs & derivatives
Dehydroepiandrosterone - blood
Dehydroepiandrosterone Sulfate
Depression, Chemical
Drug Combinations
Estradiol - blood
Estrone - blood
Female
Genital system. Reproduction
Humans
Hydrocortisone - therapeutic use
Medical sciences
Menopause
Middle Aged
Pharmacology. Drug treatments
Time Factors
Human
Chemotherapy
Treatment
Estrogen
Postmenopause
Tumor
Cortisol
Ratio
Mammary gland
Sex steroid hormone
Therapeutic protocol
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Summary:The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populations, but the mean age and weight of the groups were similar and there were no significant differences between the pretreatment serum levels of the hormones investigated. Serum oestrone and oestradiol levels were suppressed by both treatments, but there was a significantly greater suppression by AG + HC. This greater suppression is probably due to the observed increase in serum androstenedione (i.e. precursor) levels with AG alone, whilst with AG + HC these levels were found to be reduced. In terms of suppression of serum oestrogen levels it is of benefit to combine low dose AG with HC.
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ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1985.223