Synthesis, Characterization, and Evaluation of the Antimicrobial Effects and Cytotoxicity of a Novel Nanocomposite Based on Polyamide 6 and Trimetaphosphate Nanoparticles Decorated with Silver Nanoparticles

• Published in: Antibiotics (Basel) Vol. 13; no. 4; p. 340
• Main Authors: de Morais, Leonardo Antônio, Souza Neto, Francisco Nunes de, Hosida, Thayse Yumi, Dos Santos, Danilo Martins, de Almeida, Bianca Carvalho, Frollini, Elisabete, Filho, Sergio Paulo Campana, Barbosa, Debora de Barros, de Camargo, Emerson Rodrigues, Delbem, Alberto Carlos Botazzo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Agricultural societies; Antimicrobial activity; Antimicrobial agents; biocompatible materials; Biomedical materials; Cell adhesion & migration; Cell viability; Chemical elements; Contact angle; Cytotoxicity; Dental materials; Disease resistance; Free energy; Membranes; Microorganisms; Mineralization; Morphology; Nanocomposites; Nanoparticles; Phosphates; Polyamide resins; Polyamides; polymers; Silver; Spectrum analysis; Statistical analysis; Statistical methods; Tissue engineering; Toxicity; biocompatible materials; silver; nanoparticles; polymers; phosphates
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics13040340

This study aimed to develop a polymeric matrix of polyamide-6 (P6) impregnated with trimetaphosphate (TMP) nanoparticles and silver nanoparticles (AgNPs), and to evaluate its antimicrobial activity, surface free energy, TMP and Ag release, and cytotoxicity for use as a support in dental tissue. The data were subjected to statistical analysis ( < 0.05). P6 can be incorporated into TMP without altering its properties. In the first three hours, Ag was released for all groups decorated with AgNPs, and for TMP, the release only occurred for the P6-TMP-5% and P6-TMP-10% groups. In the inhibition zones, the AgNPs showed activity against both microorganisms. The P6-TMP-2.5%-Ag and P6-TMP-5%-Ag groups with AgNPs showed a greater reduction in CFU for . For , all groups showed a reduction in CFU. The P6-TMP groups showed higher cell viability, regardless of time ( < 0.05). The developed P6 polymeric matrix impregnated with TMP and AgNPs demonstrated promising antimicrobial properties against the tested microorganisms, making it a potential material for applications in scaffolds in dental tissues.