Patterns of reactivity of the monoclonal antibody 791T/36 with different tumour metastases in the liver

• Published in: British journal of cancer Vol. 54; no. 6; pp. 871 - 875
• Main Authors: HAWKEY, C. J, HOLMES, C. H, SMITH, P. G, AUSTIN, E. B, BALDWIN, R. W
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.12.1986
• Subjects: Adenocarcinoma - immunology; Adult; Aged; Antibodies, Monoclonal - immunology; Biological and medical sciences; Bronchial Neoplasms - immunology; Carcinoma, Small Cell - immunology; Colonic Neoplasms - immunology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hodgkin Disease - immunology; Humans; Immunoenzyme Techniques; Liver - immunology; Liver Neoplasms - immunology; Liver Neoplasms - secondary; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Pancreatic Neoplasms - immunology; Rectal Neoplasms - immunology; Thyroid Neoplasms - immunology; Tumors; Human; Reactivity; Immunological investigation; Liver; Digestive diseases; Tumor; Metastatic; Monoclonal antibody
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.1986.255

Reactivity of the monoclonal antibody 791T/36 with secondary malignant deposits has been investigated in frozen sections of 74 human liver biopsy specimens. There was no reactivity with hepatocytes but in some instances binding to fibrous tissues and in one case to portal tract lymphocytes was observed. Sections from 9 biopsy specimens contained malignant deposits. In seven of these 791T/36 bound either to malignant cells or to pseudoacinar contents (3 colorectal adenocarcinomas; 1 probable pancreatic adenocarcinoma; 1 medullary cell carcinoma of thyroid; 1 oat cell carcinoma of bronchus and 1 deposit of nodular sclerosing Hodgkins Disease). Two undifferentiated tumours (1 gastric adenocarcinoma and 1 oat cell bronchial carcinoma) showed no antibody binding. The histological pattern of reactivity previously reported with primary tumours appears to be similar in secondary deposits. A wider range of tumours than recognised hitherto binds 791T/36. Whether the binding to fibrous tissue seen in some instances is sufficient to cause diagnostic uncertainty when 791T/36 is used for scanning requires further investigation.