Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve

• Published in: European journal of applied physiology Vol. 108; no. 3; pp. 459 - 468
• Main Authors: Wang, You-Hua, Hu, Hao, Wang, Sheng-Peng, Tian, Zhen-Jun, Zhang, Quan-Jiang, Li, Qiu-Xia, Li, You-You, Yu, Xiao-Jiang, Sun, Lei, Li, Dong-Ling, Jia, Bing, Liu, Bing-Hang, Zang, Wei-Jin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2010; Springer; Springer Nature B.V
• Subjects: Aerobics; Animals; Apolipoproteins; Atherosclerosis; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Blood Pressure - physiology; Body Weight - physiology; Cardiac function; Cardiovascular disease; Cardiovascular Physiological Phenomena; Cholesterol; Cholinesterases - metabolism; Cytokines; Cytokines - blood; Disease Models, Animal; Exercise; Fitness training programs; Fundamental and applied biological sciences. Psychology; Heart - innervation; Heart - physiology; Heart failure; Heart Rate - physiology; Hemodynamics; Human Physiology; Hyperlipidemia; Hyperlipidemias - metabolism; Hyperlipidemias - physiopathology; Laboratory animals; Lipids; Lipids - blood; Male; Myocardium - metabolism; Occupational Medicine/Industrial Medicine; Original Article; Physical Conditioning, Animal - physiology; Physical education; Physical fitness; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2 - metabolism; Sports Medicine; Vagus Nerve - physiology; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; China; Germany; Cholinesterase-positive nerve; receptor; Blood lipids; Inflammatory cytokine; Muscarinic cholinergic (M; Cardiac function; Physical exercise; Human; Rat; Health; Rodentia; Cytokine; Metabolic diseases; Lipids; Inflammation; Vertebrata; Cholinergic receptor; Mammalia; M2 Muscarinic receptor; Hyperlipemia; Vagus nerve; Dyslipemia
• ISSN: 1439-6319; 1439-6327
• DOI: 10.1007/s00421-009-1232-1

The role of exercise training on hemodynamic parameters, blood lipid profiles, inflammatory cytokines, cholinesterase-positive nerves and muscarinic cholinergic (M 2 ) receptors expression in the heart was investigated in Sprague–Dawley male rats with hyperlipidemia (HL). The rats were subjected to a high-fat diet and exercise training for 8 weeks, and then the hemodynamic parameters, the profiles of blood lipid and inflammatory cytokines, and the expression of cholinesterase-positive nerves and M 2 receptors were measured. HL rats displayed cardiac dysfunction, dysregulation of inflammatory cytokines, and decreased cholinesterase-positive nerves and M 2 receptors expression. The combination of hyperlipidemia with exercise training (AT) restored the profiles of blood lipids and the levels of inflammatory cytokines. In addition, AT and HL + AT improved cardiac function with increasing cholinesterase-positive nerves and M 2 receptors expression. Overall, these data show that the increased expression of cholinesterase-positive nerves and M 2 receptors in the heart is partially responsible for the benefits of exercise training on cardiac function in hyperlipidemia rats.