Optical control of neuronal firing via photoinduced electron transfer in donor-acceptor conjugates

A series of porphyrin-fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effec...

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Published inChemical science (Cambridge) Vol. 7; no. 5; pp. 3331 - 3337
Main Authors Takano, Yuta, Numata, Tomohiro, Fujishima, Kazuto, Miyake, Kazuaki, Nakao, Kazuya, Grove, Wesley David, Inoue, Ryuji, Kengaku, Mineko, Sakaki, Shigeyoshi, Mori, Yasuo, Murakami, Tatsuya, Imahori, Hiroshi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
DESIGN
ENERGY
MEMBRANE
DYNAMICS
ION
TRIADS
STATE
CHARGE SEPARATION
ARRAYS
MOLECULES
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Summary:A series of porphyrin-fullerene linked molecules has been synthesized to evaluate the effects of substituents and molecular structures on their charge-separation yield and the lifetime of a final charge-separated state in various hydrophilic environments. The selected high-performance molecule effectively achieved depolarization in a plasma cell membrane by visible light as well as two-photon excitation using a near-infrared light laser. Moreover, it was revealed that the depolarization can trigger neuronal firing in rat hippocampal neurons, demonstrating the potential and versatility for controlling cell functions using light.
Bibliography:KAKEN
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ISSN:2041-6520
2041-6539
DOI:10.1039/c5sc04135j