The inherited susceptibility to cancer

The study of inherited cancer syndromes has led to the identification of over 25 genes directly involved in tumorigenesis. These genes have functions as diverse as signal transduction, cell cycle control, cell-to-cell adhesion, control of apoptosis, DNA repair and the maintenance of genome stability...

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Published inCellular and molecular life sciences : CMLS Vol. 57; no. 4; pp. 589 - 603
Main Author Guilford, P
Format Journal Article
LanguageEnglish
Published Switzerland Springer Nature B.V 01.04.2000
Birkhäuser Verlag
Subjects
Animals
Cancer
Cell adhesion & migration
Cell Communication
Cell Division
Cell Survival
DNA Repair
DNA, Neoplasm
Genetic Predisposition to Disease
Genomes
Humans
Neoplasms - genetics
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Summary:The study of inherited cancer syndromes has led to the identification of over 25 genes directly involved in tumorigenesis. These genes have functions as diverse as signal transduction, cell cycle control, cell-to-cell adhesion, control of apoptosis, DNA repair and the maintenance of genome stability. Most cancer syndromes have a dominant pattern of inheritance, due to germline loss-of-function mutation of a tumour suppressor gene. All the recessively inherited genes have been implicated in the maintenance of genome stability. This review summarises our current understanding of the functions of the major cancer susceptibility genes.
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ISSN:1420-682X
1420-9071
DOI:10.1007/PL00000721