A Prediction Model for Estimating Pulmonary Oxygen Uptake During the 6-Minute Walk Test in Organ Transplant Recipients

• Published in: Transplantation proceedings Vol. 39; no. 10; pp. 3313 - 3316
• Main Authors: Tomczak, C.R, Warburton, D.E.R, Riess, K.J, Jendzjowsky, N.G, Liang, Y, Bhambhani, Y, Haennel, R.G, Haykowsky, M.J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2007
• Subjects: Adult; Bone Marrow Transplantation - physiology; Female; Heart-Lung Transplantation - physiology; Humans; Kidney Transplantation - physiology; Liver Transplantation - physiology; Lung Transplantation - physiology; Male; Middle Aged; Oxygen Consumption - physiology; Predictive Value of Tests; Probability; Respiratory Function Tests; Surgery; Walking - physiology
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2007.10.004

Abstract We developed a multivariate prediction equation for estimating the highest obtainable pulmonary oxygen uptake (V̇O2p ) during the 6-minute walk test (6-MWT) in 54 organ transplant recipients: heart/heart-double-lung ( n = 14), kidney/kidney-pancreas ( n = 16), liver ( n = 14), double lung ( n = 8), bone marrow ( n = 2). They were of age, 48 ± 12 years. Participants performed a 6-MWT during which expired gases were collected and analyzed with a portable metabolic system interfaced with a wireless heart rate monitor. The following variables significantly contributed to the model for predicting the highest obtainable 6-MWT V̇O2p : 6-MWT distance (m), age (years), gender (male = 0, female = 1), resting heart rate, peak heart rate, weight (kg), and transplant type (kidney/kidney-pancreas = 1, other = 0), where: V̇O2p = 1.253 + 0.022 (6-MWT distance) + 0.112 (age) −3.192 (gender) −0.104 (resting heart rate) + 0.127 (peak 6-MWT heart rate) − 0.084 (weight) + 2.116 (transplant type). The explanatory variables in our final model accounted for 78% of the variance in 6-MWT V̇O2p . In conclusion, the addition of an easily estimated 6-MWT V̇O2p will provide added clinical information of functional capacity following an exercise rehabilitation intervention or during routine follow-up for organ transplant recipients.