Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure

In vitro studies have revealed that acute increases in transmural pressure increase lymphatic vessel contractile function. However, adaptive responses to prolonged changes in transmural pressure in vivo have not been reported. Therefore, we developed a novel bovine mesenteric lymphatic partial const...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of physiology. Heart and circulatory physiology Vol. 305; no. 2; pp. H203 - H210
Main Authors Dongaonkar, R M, Nguyen, T L, Quick, C M, Hardy, J, Laine, G A, Wilson, E, Stewart, R H
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 15.07.2013
Subjects
Adaptation, Physiological
Animals
Blood pressure
Blood vessels
Cattle
Constriction
Heart
Integrative Cardiovascular Physiology and Pathophysiology
Lymphatic Vessels - anatomy & histology
Lymphatic Vessels - physiology
Lymphatic Vessels - surgery
Lymphedema - physiopathology
Mesentery
Muscle Contraction
Pressure
Time Factors
lymphatic muscle
lymphangion
edema
contractility
Online AccessGet full text

Cover

More Information
Summary:In vitro studies have revealed that acute increases in transmural pressure increase lymphatic vessel contractile function. However, adaptive responses to prolonged changes in transmural pressure in vivo have not been reported. Therefore, we developed a novel bovine mesenteric lymphatic partial constriction model to test the hypothesis that lymphatic vessels exposed to higher transmural pressures adapt functionally to become stronger pumps than vessels exposed to lower transmural pressures. Postnodal mesenteric lymphatic vessels were partially constricted for 3 days. On postoperative day 3, constricted vessels were isolated, and divided into upstream (UP) and downstream (DN) segment groups, and instrumented in an isolated bath. Although there were no differences between the passive diameters of the two groups, both diastolic diameter and systolic diameter were significantly larger in the UP group than in the DN group. The pump index of the UP group was also higher than that in the DN group. In conclusion, this is the first work to report how lymphatic vessels adapt to prolonged changes in transmural pressure in vivo. Our results suggest that vessel segments upstream of the constriction adapt to become both better fluid conduits and lymphatic pumps than downstream segments.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
R. M. Dongaonkar and T. L. Nguyen contributed equally to this work.
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00677.2012