Antioxidative Activity after Rosuvastatin Treatment in Patients with Stable Ischemic Heart Disease and Decreased High Density Lipoprotein Cholesterol

• Published in: Korean circulation journal Vol. 46; no. 3; pp. 309 - 314
• Main Authors: Park, Do-Sim, Yun, Kyeong Ho, Park, Hyun Young, Rhee, Sang Jae, Kim, Nam-Ho, Oh, Seok Kyu, Jeong, Jin-Won
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Cardiology 01.05.2016; 대한심장학회
• Subjects: Original; 내과학; Hydroxymethylglutaryl-CoA; Paraoxonase; High-density lipoproteins; Reductase inhibitors
• ISSN: 1738-5520; 1738-5555
• DOI: 10.4070/kcj.2016.46.3.309

The clinical significance of statin-induced high-density lipoprotein cholesterol (HDL-C) changes is not well known. We investigated whether rosuvastatin-induced HDL-C changes can influence the anti-oxidative action of high-density lipoprotein particle. A total of 240 patients with stable ischemic heart disease were studied. Anti-oxidative property was assessed by paraoxonase 1 (PON1) activity. We compared the lipid profile and PON1 activity at baseline and at 8 weeks after rosuvastatin 10 mg treatment. Rosuvastatin treatment increased the mean HDL-C concentration by 1.9±9.2 mg/dL (6.4±21.4%). HDL-C increased in 138 patients (57.5%), but decreased in 102 patients (42.5%) after statin treatment. PON1 activity increased to 19.1% in all patients. In both, the patients with increased HDL-C and with decreased HDL-C, PON1 activity significantly increased after rosuvastatin treatment (+19.3% in increased HDL-C responder; p=0.018, +18.8% in decreased HDL-C responder; p=0.045 by paired t-test). Baseline PON1 activity modestly correlated with HDL-C levels (r=0.248, p=0.009); however, the PON1 activity evaluated during the course of the treatment did not correlate with HDL-C levels (r=0.153, p=0.075). Rosuvastatin treatment improved the anti-oxidative properties as assessed by PON1 activity, regardless of on-treatment HDL-C levels, in patients with stable ischemic heart disease.