Improvements in virological control among women conceiving on combination antiretroviral therapy in Western Europe

• Published in: AIDS (London) Vol. 27; no. 14; pp. 2312 - 2315
• Main Authors: BAILEY, Heather, TOWNSEND, Claire L, CORTINA-BORJA, Mario, THORNE, Claire
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 10.09.2013
• Subjects: Adult; AIDS/HIV; Anti-Retroviral Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral Therapy, Highly Active - methods; Antiviral agents; Biological and medical sciences; Europe; Female; HIV Infections - drug therapy; HIV Infections - virology; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Medication Adherence; Medicin och hälsovetenskap; Pharmacology. Drug treatments; Pregnancy; Treatment Failure; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Europe; Western Europe; Human; Immunopathology; Antiretroviral agent; Drug combination; Check; AIDS; Immune deficiency; Infection; Prevention; Chemotherapy; Treatment; Viral disease; Antiviral; Female; Combined treatment; Woman
• ISSN: 0269-9370; 1473-5571; 1473-5571
• DOI: 10.1097/QAD.0b013e32836378e4

Among 396 HIV-infected women conceiving on combination antiretroviral therapy and enrolled in the European Collaborative Study in 2000-2011, the proportion with virological failure (>200 copies/ml after ≥24 weeks of treatment) declined substantially from 34% in 2000-2001 to 3% in 2010-2011. In adjusted analyses, younger women and those with at least two children were at increased risk of virological failure, highlighting the importance of close monitoring and adherence support.