The Synthesis of Nuclear Histones in Early Embryogenesis

These results confirm and extend those of earlier investigations showing that actinomycin D affects the synthesis of histones in the early stages of development of the sea urchin embryo. Actinomycin D has a differential effect on the rates of synthesis of four classes of histones under a variety of...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of biological chemistry Vol. 246; no. 3; pp. 719 - 723
Main Authors Crane, Charles M., Villee, Claude A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.02.1971
American Society for Biochemistry and Molecular Biology
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:These results confirm and extend those of earlier investigations showing that actinomycin D affects the synthesis of histones in the early stages of development of the sea urchin embryo. Actinomycin D has a differential effect on the rates of synthesis of four classes of histones under a variety of conditions. It consistently and markedly inhibits the synthesis of the acid-soluble, lysine-rich Fraction f1, while greatly stimulating that of f2a, the ethanol-soluble and relatively arginine-rich one. These results strongly imply that the messenger RNAs for the synthesis of these histones are transcribed at different times.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)62472-X