The Synthesis of Nuclear Histones in Early Embryogenesis

These results confirm and extend those of earlier investigations showing that actinomycin D affects the synthesis of histones in the early stages of development of the sea urchin embryo. Actinomycin D has a differential effect on the rates of synthesis of four classes of histones under a variety of...

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Bibliographic Details
Published inThe Journal of biological chemistry Vol. 246; no. 3; pp. 719 - 723
Main Authors Crane, Charles M., Villee, Claude A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.02.1971
American Society for Biochemistry and Molecular Biology
Subjects
Alanine - metabolism
Animals
Arginine - metabolism
Carbon Isotopes
Cell Nucleus - metabolism
Dactinomycin - pharmacology
Ethanol
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Summary:These results confirm and extend those of earlier investigations showing that actinomycin D affects the synthesis of histones in the early stages of development of the sea urchin embryo. Actinomycin D has a differential effect on the rates of synthesis of four classes of histones under a variety of conditions. It consistently and markedly inhibits the synthesis of the acid-soluble, lysine-rich Fraction f1, while greatly stimulating that of f2a, the ethanol-soluble and relatively arginine-rich one. These results strongly imply that the messenger RNAs for the synthesis of these histones are transcribed at different times.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)62472-X