A Path to Insulin Independence: “The End of the Beginning”

• Published in: Cell stem cell Vol. 18; no. 4; pp. 431 - 433
• Main Authors: Stock, Peter G., German, Michael S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.04.2016
• Subjects: Bioengineering - trends; Biotechnology; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - pathology; Diabetes Mellitus, Type 1 - therapy; Humans; Insulin - immunology; Insulin-Secreting Cells - cytology; Insulin-Secreting Cells - immunology; Insulin-Secreting Cells - pathology; Insulin-Secreting Cells - transplantation
• ISSN: 1934-5909; 1875-9777
• DOI: 10.1016/j.stem.2016.03.010

Widespread application of β cell replacement to obtain insulin independence in people with type 1 diabetes requires an unlimited source of insulin-producing cells and the ability to block the pathological immune response. Recent reports in Nature Medicine and Nature Biotechnology present a creative bioengineering strategy for achieving these goals. Widespread application of β cell replacement to obtain insulin independence in people with type 1 diabetes requires an unlimited source of insulin-producing cells and the ability to block the pathological immune response. Recent reports in Nature Medicine and Nature Biotechnology present a creative bioengineering strategy for achieving these goals.