Rubischumanins A–C, new cytotoxic cyclopeptides from Rubia schumanniana

Three new cyclic hexapeptides, designated as rubischumanins A–C (1–3), together with three known ones (4–6) were isolated from the roots and rhizomes of Rubia schumanniana. The structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of these compounds was evaluated...

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Bibliographic Details
Published inTetrahedron Vol. 70; no. 42; pp. 7627 - 7631
Main Authors Huang, Mao-Bo, Zhao, Si-Meng, Zeng, Guang-Zhi, Kuang, Bin, Chen, Xiao-Qiang, Tan, Ning-Hua
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 21.10.2014
Elsevier
Subjects
Chemistry
Chemistry, Organic
Cyclopeptides
Cytotoxicity
Physical Sciences
Rubia schumanniana
Rubischumanins A–C
Science & Technology
NEDMDIHCIHZIAS-IRLBMOMYSA-N
Cyclopeptides
MEKMCKQJONKZLT-VUHJCTLOSA-N
Cytotoxicity
KCKWNDFPDOURNV-FZHXPVDJSA-N
Rubischumanins A–C
Rubia schumanniana
ANTITUMOR CYCLIC HEXAPEPTIDES
PEPTIDES
RUBIYUNNANINS
Rubischumanins A-C
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Summary:Three new cyclic hexapeptides, designated as rubischumanins A–C (1–3), together with three known ones (4–6) were isolated from the roots and rhizomes of Rubia schumanniana. The structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of these compounds was evaluated and compounds 1, 2, 4, and 5 showed cytotoxicity against A549, BGC-823, and Hela cell lines. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2014.07.105