Interactive effect of fluoride burden with calcitonin receptor gene polymorphisms on the risk of F bone injury

• Published in: International archives of occupational and environmental health Vol. 84; no. 5; pp. 533 - 538
• Main Authors: Tu, Jun, Liu, Kejian, Song, Yu’e, Zhang, Yuzeng, Cui, Caiyan, Lu, Cuirong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2011; Springer; Springer Nature B.V
• Subjects: Adult; Aluminum; Biological and medical sciences; Body Burden; Bone and Bones - drug effects; Bone Diseases - diagnosis; Bone Diseases - epidemiology; Bone Diseases - etiology; Bones; Case-Control Studies; Earth and Environmental Science; Environment; Environmental Health; Fluorides; Fluorides - adverse effects; Fluorides - blood; Genes; Genotype; Genotypes; Health risks; Humans; Injuries; Male; Medical sciences; Miscellaneous; Neurons; Occupational Diseases - diagnosis; Occupational Diseases - epidemiology; Occupational Diseases - etiology; Occupational Medicine/Industrial Medicine; Odds Ratio; Original Article; Polymorphism; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, Calcitonin - drug effects; Receptors, Calcitonin - genetics; Regression analysis; Rehabilitation; Risk factors; Traumas. Diseases due to physical agents; Asia; China; China, People's Rep., Hubei Prov; F burden; Gene polymorphisms; Interactive effect; F bone injury; Human; Toxicity; Injury; Diseases of the osteoarticular system; Fracture; Fluorides; Epidemiology; Trauma; Osteoarticular system; Gene; Calcitonin receptor; Risk factor; Predisposition; Genetics; Bone; Public health; Polymorphism
• ISSN: 0340-0131; 1432-1246
• DOI: 10.1007/s00420-010-0602-7

Purpose This study aims to examine the interactive effect of fluoride burden with calcitonin receptor (CTR) gene polymorphisms on the risk of fluoride (F) bone injury and provide the basis for determination of F bone injury risk factors. Methods In this case–control study, a total of 119 cases and 126 controls were enrolled from 2 aluminum plants in Hubei province. F burden (UF) was measured by F ion-selective electrode method. The CTR gene polymorphisms were determined using the polymerase chain reaction—restriction fragment length polymorphism (PCR–RFLP) method. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios, 95% confidence intervals (CI). Results The odds of developing F bone injury for participants in the moderate F burden group versus the mild F burden group were 4.1 (95% CI: 1.9, 8.7); the heavy F burden group versus the mild F burden group were 14.1 (95% CI: 6.5, 30.6). The odds of developing F bone injury for participants with the TC & TT genotypes versus the CC genotype were 2.6 (95% CI: 1.4, 4.7). The interactions between TC & TT genotypes and moderate, heavy F burden were significant (OR = 14.4; OR = 40.3). Conclusion The interactive effect of F burden and CTR genotype was significant, which increased the F bone injury risk.