Effect of Local Anesthesia with and without the Vasoconstrictor on Blood Glycemic Level in Diabetic Patients Undergoing Tooth Extractions

• Published in: Journal of pharmacy & bioallied science Vol. 16; no. Suppl 4; pp. S3329 - S3331
• Main Authors: Kumari, Sujata, Singh, Chandandeep, Jaitly, Riya, Kondaveeti, Suresh B., Morsy, Mohamed S. M., Qurishi, Ahtesham A., Ojha, Akshaya
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.12.2024; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: adrenaline; Anesthesia; Anesthetics; Blood levels; Care and treatment; Dextrose; Diabetes; Diabetes mellitus; diabetic patient; Diabetics; Epinephrine; Glucose; glycemic level; Lidocaine; Local anesthesia; Local anesthetics; Original Research; Statistical analysis; Tooth extractions; Toxicity; Type 2 diabetes; vasoconstrictor; Vasoconstrictors; India; glycemic level; Adrenaline; diabetic patient; vasoconstrictor
• ISSN: 0976-4879; 0975-7406
• DOI: 10.4103/jpbs.jpbs_805_24

ABSTRACT Background: Vasoconstrictors with local anesthetics provide a bloodless as well as toxicity-free area for effortless extraction tooth. This study was conducted to evaluate the effect of local anesthesia (LA) with adrenaline and without adrenaline on blood glycemic levels in patients undergoing tooth extraction. Material and Method: A total of 120 patients who require multiple extractions consisting of 60 healthy and 60 diabetic patients in need of multiple extractions were selected for this study. Subjects were given plain lignocaine on their 1st visit and tooth extraction was performed. After seven days lignocaine with 1:80,000 adrenaline was administered to the same patient for a similar procedure. Blood glycemic levels were estimated at regular intervals that is before and right away after the administration of LA) 10 and 20 min on both occasions. Results: Comparing the glucose level at 10 min and 20 min showed a statistically significant distinction (P < 0.001) in healthy subjects. Comparing the glucose level at 10 min and 20 min intervals showed highly statistically significant distinction (P < 0.001) in diabetic subjects (P < 0.001). Conclusion: LA with vasoconstrictor leads to an elevation in blood glycemic level in patients with NIDDM.