Activation of Cdk2 is a requirement for antigen‐mediated thymic negative selection
Apoptosis plays a critical role in T cell development and thymic selection. Thymocytes which undergo antigen‐induced negative selection have been demonstrated to die by apoptosis. Despite this, relatively little is known about the specific apoptotic pathway involved in negative selection. We have ex...
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Published in | European journal of immunology Vol. 30; no. 2; pp. 709 - 713 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY‐VCH Verlag GmbH
01.02.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Apoptosis plays a critical role in T cell development and thymic selection. Thymocytes which undergo antigen‐induced negative selection have been demonstrated to die by apoptosis. Despite this, relatively little is known about the specific apoptotic pathway involved in negative selection. We have examined the role of cyclin‐dependent kinase 2 (Cdk2), a key regulator of thymocyte apoptosis, in this process. Stimulation of thymocytes with cognate antigen leads to a large increase in Cdk2 kinase activity. We also show that pharmacological inhibitors of Cdk2 block thymocyte apoptosis in response to antigen. Our data show that Cdk2 activity is essential for the apoptotic pathway used in negative selection. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0014-2980 1521-4141 |
DOI: | 10.1002/1521-4141(200002)30:2<709::AID-IMMU709>3.0.CO;2-9 |