Combination therapy - deferasirox and deferoxamine - in thalassemia major patients in emerging countries with limited resources

• Published in: Transfusion medicine (Oxford, England) Vol. 25; no. 1; pp. 8 - 12
• Main Authors: Arandi, N., Haghpanah, S., Safaei, S., Zahedi, Z., Ashrafi, A., Eatemadfar, P., Zarei, T., Radwan, A. H, Taher, A. T, Karimi, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2015
• Subjects: Adolescent; Adult; Benzoates - administration & dosage; beta-Thalassemia - blood; beta-Thalassemia - drug therapy; chelation therapy; Child; deferasirox; deferoxamine; Deferoxamine - administration & dosage; Developing Countries; Drug Therapy, Combination; Female; Ferritins - blood; Humans; Iran; Lebanon; Male; serum ferritin; Siderophores - administration & dosage; Triazoles - administration & dosage; β-Thalassemia; Lebanon; Iran; chelation therapy; deferoxamine; serum ferritin; deferasirox; β-Thalassemia
• ISSN: 0958-7578; 1365-3148
• DOI: 10.1111/tme.12188

SUMMARY Background The problem of iron‐overload observed in thalassemia patients can be overcome using chelating agents such as deferiprone (Ferroprox®), deferasirox (Exjade®) and deferoxamine (Desferal®). Although these drugs can be used as monotherapy, combined therapy, especially deferiprone with deferoxamine, has led to promising outcomes in various studies. Methods and Materials In this quasi‐experimental study, serum ferritin levels were evaluated in 32 β‐thalassemia major patients with severe iron overload before and after receiving combined deferasirox (30–40 mg kg−1 day−1) and deferoxamine (40–50 mg kg−1 day−1) 2 days a week. This study was conducted from September 2012 to September 2013 in Southern Iran. Results The mean of serum ferritin levels significantly reduced from 4031 ± 1955 to 2416 ± 1653 ng mL−1 after 12 months of therapy (P < 0·001). Echocardiograph findings showed significant improvement 1year after end of the study (P < 0·001). No drug toxicity was observed by monitoring serum creatinine, liver enzymes and blood urea nitrogen (BUN) during the study period. We observed no correlation between mean serum ferritin change and age (P = 0·87). In addition, the mean serum ferritin change did not differ between male and female thalassemia patients (P = 0·454). No difference in mean serum ferritin change was observed between patients who had undergone splenectomy compared to those who had not done so (P = 0·307). Conclusion The study suggests that combination chelating therapy with deferasirox and deferoxamine can effectively reduce iron burden in β‐thalassemia major patients with heavy iron overload without any significant complications.