Total Synthesis of Hopeahainol A and Hopeanol

Similar, but different: Possessing almost the same but not identical structures, the recently discovered natural products hopeahainol A (1) and hopeanol (2) exhibit important but differing biological properties (see structures). Their first total synthesis has now been achieved through a series of n...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 48; no. 19; pp. 3440 - 3443
Main Authors Nicolaou, K.C, Wu, T. Robert, Kang, Qiang, Chen, David Y.-K
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.01.2009
WILEY‐VCH Verlag
Wiley
Subjects
cascade reactions
Chemistry
Chemistry, Multidisciplinary
Dipterocarpaceae - chemistry
Dipterocarpaceae - metabolism
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemistry
Molecular Structure
natural products
Phenols - chemical synthesis
Phenols - chemistry
Physical Sciences
polyphenols
Science & Technology
total synthesis
cascade reactions
natural products
polyphenols
total synthesis
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Summary:Similar, but different: Possessing almost the same but not identical structures, the recently discovered natural products hopeahainol A (1) and hopeanol (2) exhibit important but differing biological properties (see structures). Their first total synthesis has now been achieved through a series of novel cascade reactions and skeletal rearrangements.
Bibliography:http://dx.doi.org/10.1002/anie.200900438
We thank Ms. Doris Tan (ICES) for assistance with high resolution mass spectroscopy (HRMS) measurements. Financial support for this work was provided by A*STAR, Singapore.
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200900438