Nine New Norlabdane Diterpenoids from the Leaves of Austroeupatorium inulifolium

Nine new norlabdane diterpenoids were isolated from the leaves of Austroeupatorium inulifolium collected in Indonesia. All of them have an acyl‐furan unit connected to C(11), and oxygenated functions at C(2) and C(3). The structure elucidations and the assignment of the absolute configurations of th...

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Bibliographic Details
Published inHelvetica chimica acta Vol. 94; no. 2; pp. 313 - 326
Main Authors Saito, Yoshinori, Matsuo, Sachie, Sutoyo, Suyatno, Tori, Motoo
Format Journal Article
LanguageEnglish
Published Zürich WILEY-VCH Verlag 01.02.2011
WILEY‐VCH Verlag
Wiley
Subjects
Antimicrobial activity
Austroeupatorium inulifolium
Chemistry
Chemistry, Multidisciplinary
Cytotoxic activity
Diterpenoids
Norlabdane diterpenoids
Physical Sciences
Science & Technology
HIYODORILACTONE-B
TUMOR INHIBITORS
PHYLOGENY
STRUCTURAL ELUCIDATION
SEQUENCE DATA
EUPATORIUM-CUNEIFOLIUM
INULAEFOLIUM
SESQUITERPENE LACTONES
ASTERACEAE
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Summary:Nine new norlabdane diterpenoids were isolated from the leaves of Austroeupatorium inulifolium collected in Indonesia. All of them have an acyl‐furan unit connected to C(11), and oxygenated functions at C(2) and C(3). The structure elucidations and the assignment of the absolute configurations of the isolated natural products were carried out by extensive spectroscopic analysis and the extended Mosher method, as well as chemical correlations. Antimicrobial activities and cytotoxicity against HL‐60 cells were determined using bioassays.
Bibliography:istex:F45233194949DBBEA1BFF22832B6886C34CCD805
ArticleID:HLCA201000207
ark:/67375/WNG-XP211T3V-J
ISSN:0018-019X
1522-2675
DOI:10.1002/hlca.201000207