E2F target genes and cell-cycle checkpoint control

• Published in: BioEssays Vol. 21; no. 3; pp. 221 - 230
• Main Authors: Lavia, Patrizia, Jansen-Dürr, Pidder
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.03.1999
• Subjects: Animals; Apoptosis; Carrier Proteins; Cell Cycle - physiology; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; Gene Expression Regulation; GTP-Binding Proteins - genetics; Humans; Nuclear Proteins - genetics; ran GTP-Binding Protein; Retinoblastoma-Binding Protein 1; S Phase; Signal Transduction; Transcription Factor DP1; Transcription Factors - genetics; Transcription Factors - metabolism; Transcription, Genetic
• ISSN: 0265-9247; 1521-1878
• DOI: 10.1002/(SICI)1521-1878(199903)21:3<221::AID-BIES6>3.0.CO;2-J

In this review, we will focus on the role played by transcription factors of the E2F/DP family in controlling the expression of genes that carry out important cell‐cycle control functions, thereby ensuring ordered progression through the mammalian cell division cycle. The emerging picture is that cell‐cycle progression depends on the execution of a regulatory cascade of gene expression, driven by E2F/DP transcription factors, which are in turn regulated by the products of some of these genes. That E2F factors are potent regulators of cell‐cycle checkpoints in mammalian cells is supported by experiments demonstrating that ectopic expression of individual E2F family members is sufficient to modulate cell proliferation and apoptosis. It is also clear that deregulation of E2F activity will result in the loss of particular checkpoint controls, thereby predisposing cells to malignant conversion. BioEssays 21:221–230. 1999. © 1999 John Wiley & Sons, Inc.