Functionalized Cyclodextrins as First and Second Coordination Sphere Ligands for Aqueous Organometallic Catalysis

• Published in: European journal of inorganic chemistry Vol. 2012; no. 10; pp. 1571 - 1578
• Main Authors: Hapiot, Frédéric, Bricout, Hervé, Tilloy, Sébastien, Monflier, Eric
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.04.2012; WILEY‐VCH Verlag
• Subjects: Biphasic catalysis; Cyclodextrins; Host-guest systems; N,P ligands; P ligands; Phosphane li­gands
• ISSN: 1434-1948; 1099-0682
• DOI: 10.1002/ejic.201101316

Supramolecular catalysis now forms a viable and challenging interdisciplinary topic that drives chemists to design new ligands and their metal complexes. Functionalized cyclodextrins (CDs) have attracted particular attention in this respect because of their molecular recognition and metal coordination ability. They can act both as first‐coordination‐sphere ligands through coordination of a phosphanyl or amino group onto the metal and as second‐coordination‐sphere ligands because of the inclusion of a guest molecule (substrate or ligand) inside their cavity. These combined features make functionalized CDs very special objects. The present review seeks to address the scope of these supramolecular entities as ligands for the elaboration of novel organometallic complexes for aqueous catalysis. The scope and limitations of the use of functionalized cyclodextrins as first‐ and second‐sphere ligands in aqueous catalysis are discussed with emphasis on the role of the reaction solvent and the interaction between the functional group and the cyclodextrin cavity.