Identification of a new HLA-DRB5 allele, DRB50112, by routine PCR-SSP

:  We describe the identification of a new HLA‐DRB5 allele found in two members of a British Caucasoid family. Genomic analysis of exon 2 revealed a novel sequence. The name DRB5*0112 has been assigned to this allele by the WHO Nomenclature Committee, and the EMBL sequence database accession number...

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Bibliographic Details
Published inTissue antigens Vol. 62; no. 6; pp. 554 - 555
Main Authors Atkinson, D.C., Jobson, S.E., Dunn, P.P.J., Briggs, D.C.
Format Journal Article
LanguageEnglish
Published Oxford, UK Munksgaard International Publishers 01.12.2003
Subjects
Alleles
Amino Acid Sequence
DNA sequencing
Exons
HLA-DR Antigens - genetics
HLA-DRB5
HLA-DRB5 Chains
Humans
Male
Molecular Sequence Data
PCR-SSP
Polymerase Chain Reaction - methods
Sequence Alignment
Sequence Homology, Amino Acid
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Summary::  We describe the identification of a new HLA‐DRB5 allele found in two members of a British Caucasoid family. Genomic analysis of exon 2 revealed a novel sequence. The name DRB5*0112 has been assigned to this allele by the WHO Nomenclature Committee, and the EMBL sequence database accession number for this is AJ427352. DRB5*0112 has several unique sequence features when compared to other DRB5 alleles, and comparison with all known DRB1/3/4/5 alleles indicates this to have arisen as a result of intraexonic recombination between a DRB5‐containing haplotype and one carrying DRB1*09.
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ISSN:0001-2815
1399-0039
DOI:10.1046/j.1399-0039.2003.00124.x