Significance of inflammation on standard semen analysis in chronic prostatitis/chronic pelvic pain syndrome

• Published in: Andrologia Vol. 35; no. 3; pp. 152 - 156
• Main Authors: Ludwig, M., Vidal, A., Huwe, P., Diemer, T., Pabst, W., Weidner, W.
• Format: Journal Article
• Language: English
• Published: Berlin, Germany Blackwell Verlag GmbH 01.06.2003; Blackwell
• Subjects: Biological and medical sciences; Chronic Disease; Chronic pelvic pain syndrome; chronic prostatitis; Gynecology. Andrology. Obstetrics; Humans; Inflammation - pathology; Male; Male genital diseases; Medical sciences; Non tumoral diseases; Pelvic Pain - pathology; Prostatitis - pathology; Semen; standard ejaculate analysis; Human; Chronic; Urinary system disease; Prostate disease; Semen; Chronic pelvic pain syndrome-chronic prostatitis-standard ejaculate analysis; Ejaculate; Inflammation; Prostatitis; Male genital diseases; Pelvic pain
• ISSN: 0303-4569; 1439-0272
• DOI: 10.1046/j.1439-0272.2003.00553.x

The impact of defined urogenital inflammations on standard ejaculate parameters is still a matter of controversial debate. Basic spermiogram parameters has been analysed in patients with inflammatory and noninflammatory chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS–NIH IIIA/IIIB) with regard to indicators of inflammation in prostatic secretions and/or the ejaculate. A total of 112 consecutive patients symptomatic for chronic pelvic pain were included in the study. All of them underwent a ‘four glass‐test’ including leukocyte determination in expressed prostatic secretions followed by ejaculate analysis according to WHO. The analysis included pH, volume, total sperm count, sperm density, motility, morphology (Shorr stain), vitality (eosin stain), and counting of peroxidase positive leukocytes (PPL). Patients were first subgrouped according to elevated leukocyte counts in prostatic secretions, and then according to the number of PPL in semen. Leukocytes neither in the prostatic secretions nor in the ejaculate were associated with reduced standard semen parameters. Our data supports previous results that elevated leukocyte counts in prostatic secretions and in ejaculate, as indicators of inflammation have no negative impact on total sperm count, sperm density, motility, morphology, and sperm vitality in patients with CP/CPPS.