effects of five weeks treatment with dinitro-o-cresol- or trifluralin-containing pesticides on the germ cells of male mice

The effects of two pesticides, the insecticide-herbicide Krezonit E, which contains 50% dinitro-o-cresol, and the herbicide Olitref, which contains 26% trifluralin (2,6-dinitro-N,N-dipropyl-4-trifluoromethylaniline), on the gonads and germ cells of male mice were studied. The pesticides were given t...

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Bibliographic Details
Published inJournal of applied toxicology Vol. 2; no. 4; pp. 179 - 180
Main Authors Nehez, M, Selypes, A, Paldy, A, Mazzag, E, Berencsi, G
Format Journal Article
LanguageEnglish
Published England 01.08.1982
Subjects
agrochemicals
Animals
Chromosome Aberrations
Cresols - toxicity
Dinitrocresols - toxicity
Herbicides - toxicity
Male
Mice
Mice, Inbred Strains
Mutagens
pesticides
Spermatozoa - drug effects
Toluidines - toxicity
Trifluralin - toxicity
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Summary:The effects of two pesticides, the insecticide-herbicide Krezonit E, which contains 50% dinitro-o-cresol, and the herbicide Olitref, which contains 26% trifluralin (2,6-dinitro-N,N-dipropyl-4-trifluoromethylaniline), on the gonads and germ cells of male mice were studied. The pesticides were given twice a week for 5 weeks in i.p. doses of 0.6 mg kg-1 for Krezonit E and 6.0 mg kg-1 for Olitref. These doses are 1% of the i.p. LD50. Cytogenic analysis of germ cells carried out from 3 weeks onwards after the last treatment day showed that Olitref significantly increased the frequency of germinal chromosomal abnormalities at 6-7 weeks after treatment. This pesticide increased the frequency of autosomal univalents X/Y separations at meiotic metaphase and multivalent configurations. Krezonit E did not increase significantly the number of chromosomal abnormalities, although there was some increase at 3 weeks, mainly in the form of autosomal univalents.
ISSN:0260-437X
1099-1263
DOI:10.1002/jat.2550020402