Identification of a new mouse Cd1d2 allele
Summary The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele...
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| Published in | European journal of immunogenetics Vol. 31; no. 1; pp. 1 - 3 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing, Ltd
01.02.2004
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Summary
The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele for Cd1d2 characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine. |
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| AbstractList | Summary
The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele for Cd1d2 characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine. The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele for Cd1d2 characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine. |
| Author | Pérez-Rosado, A. Martínez-Naves, E. Parra-Cuadrado, J. F. Gozalbo-López, B. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15009173$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nri854 10.4049/jimmunol.162.8.4560 10.1016/S0065-2776(08)60629-X 10.4049/jimmunol.146.2.768 10.1002/ijc.10141 10.1146/annurev.immunol.17.1.297 10.1126/science.278.5343.1626 10.1034/j.1399-0039.1999.530604.x |
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| References_xml | – volume: 17 start-page: 297 year: 1999 article-title: The CD1 system: antigen‐ presenting molecules for T cell recognition of lipids and glycolipids publication-title: Annual Review of Immunology – volume: 162 start-page: 4560 year: 1999 article-title: Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1‐deficient mice publication-title: Journal of Immunology – volume: 278 start-page: 1626 year: 1997 article-title: CD1d‐restricted and TCR‐mediated activation of valpha14 NKT cells by glycosylceramides publication-title: Science – volume: 59 start-page: 1 year: 1995 article-title: The CD1 family: a third lineage of antigen‐presenting molecules publication-title: Advances in Immunology – volume: 44 start-page: 331 year: 2000 article-title: Bulging medial edge epithelial cells and palatal fusion publication-title: International Journal of Developmental Biology – volume: 146 start-page: 768 year: 1991 article-title: Isolation and expression of cDNA encoding the murine homologues of CD1 publication-title: Journal of Immunology – volume: 2 start-page: 557 year: 2002 article-title: The unconventional lifestyle of NKT cells publication-title: Nature Review of Immunology – volume: 53 start-page: 545 year: 1999 article-title: Single strand conformational polymorphism analysis of human CD1 genes in different ethnic groups publication-title: Tissue Antigens – volume: 98 start-page: 389 year: 2002 article-title: Regulation of CD1d expression by murine tumor cells: escape from immunosurveillance or alternate target molecules? publication-title: International Journal of Cancer – volume: 44 start-page: 331 year: 2000 ident: e_1_2_5_7_1 article-title: Bulging medial edge epithelial cells and palatal fusion publication-title: International Journal of Developmental Biology contributor: fullname: Martínez‐Alvarez C. – ident: e_1_2_5_6_1 doi: 10.1038/nri854 – volume: 162 start-page: 4560 year: 1999 ident: e_1_2_5_3_1 article-title: Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1‐deficient mice publication-title: Journal of Immunology doi: 10.4049/jimmunol.162.8.4560 contributor: fullname: Chen Y.H. – ident: e_1_2_5_9_1 doi: 10.1016/S0065-2776(08)60629-X – volume: 146 start-page: 768 year: 1991 ident: e_1_2_5_2_1 article-title: Isolation and expression of cDNA encoding the murine homologues of CD1 publication-title: Journal of Immunology doi: 10.4049/jimmunol.146.2.768 contributor: fullname: Balk S.P. – ident: e_1_2_5_4_1 doi: 10.1002/ijc.10141 – ident: e_1_2_5_10_1 doi: 10.1146/annurev.immunol.17.1.297 – ident: e_1_2_5_5_1 doi: 10.1126/science.278.5343.1626 – ident: e_1_2_5_8_1 doi: 10.1034/j.1399-0039.1999.530604.x |
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The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The... The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function... |
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| SubjectTerms | Alanine - chemistry Alleles Amino Acid Sequence Animals Antigens, CD1 - genetics Antigens, CD1d Base Sequence Genetic Variation Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred NOD Molecular Sequence Data Point Mutation Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Single-Stranded Conformational Sequence Analysis, DNA Sequence Homology, Nucleic Acid Valine - chemistry |
| Title | Identification of a new mouse Cd1d2 allele |
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