Identification of a new mouse Cd1d2 allele

• Published in: European journal of immunogenetics Vol. 31; no. 1; pp. 1 - 3
• Main Authors: Gozalbo-López, B., Pérez-Rosado, A., Parra-Cuadrado, J. F., Martínez-Naves, E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing, Ltd 01.02.2004
• Subjects: Alanine - chemistry; Alleles; Amino Acid Sequence; Animals; Antigens, CD1 - genetics; Antigens, CD1d; Base Sequence; Genetic Variation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Valine - chemistry
• ISSN: 0960-7420; 1365-2370
• DOI: 10.1111/j.1365-2370.2004.00431.x

Summary The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele for Cd1d2 characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine.